Brand  (β version)

PDB ID: 1JCS

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Ligands
Code Name Style Show Link
ACY Acetic acid PoSSuM
FII [(3,7,11-trimethyl-dodeca-2,6,10-trienyloxycarbamoyl)-methyl]-phosphonic acid PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
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Structure summary

Code : 1JCS   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : CRYSTAL STRUCTURE OF RAT PROTEIN FARNESYLTRANSFERASE COMPLEXED WITH THE PEPTIDE SUBSTRATE TKCVFM AND AN ANALOG OF FARNESYL DIPHOSPHATE
Release Data : 2001-11-02
Compound :
mol_id molecule chains synonym
1 PROTEIN FARNESYLTRANSFERASE, ALPHA SUBUNIT A CAAX FARNESYLTRANSFERASE ALPHA SUBUNIT; RAS PROTEINS PRENYLTRANSFERASE ALPHA; FTASE-ALPHA; PRENYL-PROTEIN TRANSFERASE RAM2 HOMOLOG
ec: 2.5.1.-
fragment: ALPHA SUBUNIT
mol_id molecule chains synonym
2 PROTEIN FARNESYLTRANSFERASE, BETA SUBUNIT B CAAX FARNESYLTRANSFERASE BETA SUBUNIT; RAS PROTEINS PRENYLTRANSFERASE BETA; FTASE-BETA; PRENYL-PROTEIN TRANSFERASE DPR1/RAM1 SUBUNIT
ec: 2.5.1.-
fragment: BETA SUBUNIT
mol_id molecule chains
3 SYNTHETIC HEXAPEPTIDE TKCVFM C
other_details: NON-SUBSTRATE INHIBITOR
Source :
mol_id organism_scientific organism_common expression_system
1 Rattus norvegicus  (taxid:10116) Norway rat Spodoptera frugiperda  (taxid:7108)
expression_system_common: Fall armyworm
expression_system_atcc_number: 63134
mol_id organism_scientific organism_common expression_system
2 Rattus norvegicus  (taxid:10116) Norway rat Spodoptera frugiperda  (taxid:7108)
expression_system_common: Fall armyworm
expression_system_atcc_number: 63134
mol_id organism_scientific
3
synthetic: yes
Authors : Long, S.B., Casey, P.J., Beese, L.S.
Keywords : FTASE, PFT, PFTASE, FT, FPT, FARNESYLTRANSFERASE, FARNESYL TRANSFERASE, FARNESYL PROTEIN TRANSFERASE, CAAX, RAS, CANCER, INHIBITOR, TRANSFERASE, transferase-transferase inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 2.20 Å )
Citation :

The crystal structure of human protein farnesyltransferase reveals the basis for inhibition by CaaX tetrapeptides and their mimetics.

Long, S.B.,Hancock, P.J.,Kral, A.M.  et al.
(2001)  Proc.Natl.Acad.Sci.USA  98 : 12948 - 12953

PubMed: 11687658
DOI: 10.1073/pnas.241407898

The Basis for K-Ras4B Binding Specificity to Protein Farnesyltransferase Revealed by 2A Resolution Ternary Complex Structures

Long, S.B.,Casey, P.J.,Beese, L.S.
(2000)  Structure  8 : 209 - 222

DOI: 10.1016/S0969-2126(00)00096-4

Crystal Structure of Protein Farnesyltransferase at 2.25A Resolution

Park, H.-W.,Boduluri, S.R.,Moomaw, J.F.  et al.
(1997)  Science  275 : 1800 - 1804

DOI: 10.1126/science.275.5307.1800

Reaction

Chain : A
UniProt : Q04631 (FNTA_RAT)
Reaction: EC: Evidence:
Physiological Direction:
(2E,6E)-farnesyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-(2E,6E)-farnesyl-L-cysteinyl-[protein] 2.5.1.58 PubMed:12657282, PubMed:18844669, PubMed:19219049, PubMed:22963166
-
geranylgeranyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-geranylgeranyl-L-cysteinyl-[protein] 2.5.1.59 PubMed:14609943, PubMed:19219049
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Chain : B
UniProt : Q02293 (FNTB_RAT)
Reaction: EC: Evidence:
Physiological Direction:
(2E,6E)-farnesyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-(2E,6E)-farnesyl-L-cysteinyl-[protein] 2.5.1.58 PubMed:10673434, PubMed:18844669, PubMed:19219049, PubMed:19246009, PubMed:22963166
-