Brand  (β version)

PDB ID: 1IT6

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Ligands
Code Name Style Show Link
MN Manganese (II) ion PoSSuM
CYU Calyculin a PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1IT6   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN CALYCULIN A AND THE CATALYTIC SUBUNIT OF PROTEIN PHOSPHATASE 1
Release Data : 2002-05-22
Compound :
mol_id molecule chains
1 SERINE/THREONINE PROTEIN PHOSPHATASE 1 GAMMA (PP1-GAMMA) CATALYTIC SUBUNIT A,B
ec: 3.1.3.16
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
Authors : Kita, A., Matsunaga, S., Takai, A., Kataiwa, H., Wakimoto, T., Fusetani, N., Isobe, M., Miki, K.
Keywords : HYDROLASE-INHIBITOR COMPLEX, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 2.0 Å )
Citation :

Crystal structure of the complex between calyculin A and the catalytic subunit of protein phosphatase 1.

Kita, A.,Matsunaga, S.,Takai, A.  et al.
(2002)  Structure  10 : 715 - 724

PubMed: 12015153
DOI: 10.1016/S0969-2126(02)00764-5

Reaction

Chain : A, B
UniProt : P36873 (PP1G_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate 3.1.3.16 PubMed:15280359, PubMed:35768504, PubMed:35831509
-
O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate 3.1.3.16 PubMed:15280359
-
Cofactor: Evidence: Note:
Mn(2+) ECO:0000269 | PubMed:11535607
ECO:0000269 | PubMed:15280359
ECO:0000269 | PubMed:35768504
Binds 2 manganese ions per subunit.