Het-PDB Navi2 (PDB: 1IHT)

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Ligands
Code	Name		Style	Show	Link

Non-standard Residues
Code	Name	Show
A5R	Amino{[(4s)-4-amino-9-carboxy-5-oxononyl]amino}methaniminium
DPN	D-phenylalanine
FBE	(3e)-5-aminopent-3-enoic acid

Glycosylation
Code	Name	Emphasize

Modification
Code	Name	Show
ACE	Acetyl group

Download interaction data: 1IHT

Code :

1IHT PDBj RCSB PDB PDBe

Header :

HYDROLASE/HYDROLASE INHIBITOR

Title :

CRYSTAL STRUCTURE OF THE COMPLEX OF HUMAN ALPHA-THROMBIN AND NON-HYDROLYZABLE BIFUNCTIONAL INHIBITORS, HIRUTONIN-2 AND HIRUTONIN-6

Release Data :

1994-01-31

Compound :

mol_id	molecule	chains
1	ALPHA-THROMBIN (SMALL SUBUNIT)	L
	ec: 3.4.21.5

mol_id	molecule	chains
2	ALPHA-THROMBIN (LARGE SUBUNIT)	H
	ec: 3.4.21.5

mol_id	molecule	chains
3	HIRUTONIN-6	I

Source :

mol_id	organism_scientific	organism_common
1	Homo sapiens (taxid:9606)	Human

mol_id	organism_scientific	organism_common
2	Homo sapiens (taxid:9606)	Human

mol_id	organism_scientific
3
	synthetic: yes

Authors :

Zdanov, A., Cygler, M.

Keywords :

SERINE PROTEINASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX

Exp. method :

X-RAY DIFFRACTION ( 2.1 Å )

Citation :

Crystal structure of the complex of human alpha-thrombin and nonhydrolyzable bifunctional inhibitors, hirutonin-2 and hirutonin-6.

Zdanov, A.,Wu, S.,DiMaio, J. et al.
(1993) Proteins 17 : 252 - 265

Chain :

UniProt :

P00734 (THRB_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
Selective cleavage of Arg-\|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.	3.4.21.5	-
	-	-

PDB ID: 1IHT