Brand  (β version)

PDB ID: 1I5R

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Ligands
Code Name Style Show Link
HYC O5'-[9-(3,17b-dihydroxy-1,3,5(10)-estratrien-16b-yl)-nonanoyl]adenosine PoSSuM
GOL Glycerol PoSSuM
Non-standard Residues
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Structure summary

Code : 1I5R   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : TYPE 1 17-BETA HYDROXYSTEROID DEHYDROGENASE EM1745 COMPLEX
Release Data : 2003-03-11
Compound :
mol_id molecule chains synonym
1 TYPE 1 17 BETA-HYDROXYSTEROID DEHYDROGENASE A ESTRADIOL 17 BETA-DEHYDROGENASE 1, PLACENTAL 17-BETA-HYDROXYSTEROID DEHYDROGENASE
ec: 1.1.1.62
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
expression_system_common: Fall armyworm
expression_system_strain: SF9
expression_system_vector_type: BACULOVIRUS
Authors : Qiu, W., Campbell, R.L., Boivin, P., Poirier, D., Lin, S.-X.
Keywords : DEHYDROGENASE, 17BETA-HYDROXYSTEROID, HYBRID, INHIBITOR, OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 1.6 Å )
Citation :

A concerted, rational design of type 1 17beta-hydroxysteroid dehydrogenase inhibitors: estradiol-adenosine hybrids with high affinity

Qiu, W.,Campbell, R.L.,Gangloff, A.  et al.
(2002)  FASEB J.  16 : 1829 - 1831

PubMed: 12223444

Reaction

Chain : A
UniProt : P14061 (DHB1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
17beta-estradiol + NAD(+) = estrone + H(+) + NADH 1.1.1.62 PubMed:8994190
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17beta-estradiol + NADP(+) = estrone + H(+) + NADPH 1.1.1.62 UniProtKB:P51656
right-to-left
NADP(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADPH 1.1.1.51 UniProtKB:P51656
right-to-left