Brand  (β version)

PDB ID: 1HVB

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Ligands
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CEH 5-{3-(S)-(4-(R)-acetylamino-4-carboxy-butyrylamino)-3-[1-(R)-(1-(R)-carboxy-ethylcarbamoyl)-ethylcarbamoyl]-propyl}-2-( carboxy-phenylacetylamino-methyl)-3,6-dihydro-2h-[1,3]thiazine-4-carboxylic acid PoSSuM
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Structure summary

Code : 1HVB   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : CRYSTAL STRUCTURE OF STREPTOMYCES R61 DD-PEPTIDASE COMPLEXED WITH A NOVEL CEPHALOSPORIN ANALOG OF CELL WALL PEPTIDOGLYCAN
Release Data : 2001-02-07
Compound :
mol_id molecule chains synonym
1 D-ALANYL-D-ALANINE CARBOXYPEPTIDASE A DD-PEPTIDASE, DD-CARBOXYPEPTIDASE
ec: 3.4.16.4
Source :
mol_id organism_scientific
1 Streptomyces sp.  (taxid:31952)
strain: R61
Authors : McDonough, M.A., Lee, W., Silvaggi, N.R., Mobashery, S., Kelly, J.A.
Keywords : Protein-cephalosporin complex, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 1.17 Å )
Citation :

A 1.2-A snapshot of the final step of bacterial cell wall biosynthesis.

Lee, W.,McDonough, M.A.,Kotra, L.  et al.
(2001)  Proc.Natl.Acad.Sci.USA  98 : 1427 - 1431

PubMed: 11171967
DOI: 10.1073/pnas.98.4.1427

Binding of Cephalothin and Cefotaxime to D-Ala-D-Ala-Peptidase Reveals A Functional Basis of a Natural Mutation in a Low-Affinity Penicillin-Binding Protein and in Extended-Spectrum Beta-Lactamases

Kuzin, A.P.,Liu, H.,Kelly, J.A.  et al.
(1995)  Biochemistry  34 : 9532 - 9540

The Refined Crystallographic Structure of a DD-Peptidase Penicillin-target Enzyme at 1.6 Angstrom Resolution

Kelly, J.A.,Kuzin, A.P.
(1995)  J.Mol.Biol.  254 : 223 - 236

DOI: 10.1006/jmbi.1995.0613

Reaction

Chain : A
UniProt : P15555 (DAC_STRSR)
Reaction: EC: Evidence:
Physiological Direction:
Preferential cleavage: (Ac)2-L-Lys-D-Ala-|-D-Ala. Also transpeptidation of peptidyl-alanyl moieties that are N-acyl substituents of D-alanine. 3.4.16.4 -
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