Brand  (β version)

PDB ID: 1HDC

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Ligands
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CBO Carbenoxolone PoSSuM
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Structure summary

Code : 1HDC   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : MECHANISM OF INHIBITION OF 3ALPHA,20BETA-HYDROXYSTEROID DEHYDROGENASE BY A LICORICE-DERIVED STEROIDAL INHIBITOR
Release Data : 1995-02-07
Compound :
mol_id molecule chains
1 3-ALPHA, 20 BETA-HYDROXYSTEROID DEHYDROGENASE A,B,C,D
ec: 1.1.1.53
Source :
mol_id organism_scientific
1 Streptomyces exfoliatus  (taxid:1905)
Authors : Ghosh, D.
Keywords : OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 2.20 Å )
Citation :

Mechanism of inhibition of 3 alpha, 20 beta-hydroxysteroid dehydrogenase by a licorice-derived steroidal inhibitor.

Ghosh, D.,Erman, M.,Wawrzak, Z.  et al.
(1994)  Structure  2 : 973 - 980

PubMed: 7866748
DOI: 10.1016/S0969-2126(94)00099-9

Inhibition of Streptomyces Hydrogenans 3Alpha,20Beta-Hydroxysteroid Dehydrogenase by Licorice-Derived Compounds and Crystallization of an Enzyme-Cofactor-Inhibitor Complex

Ghosh, D.,Erman, M.,Pangborn, W.  et al.
(1992)  J.Steroid Biochem.Mol.Biol.  42 : 849

Reaction

Chain : A, B, C, D
UniProt : P19992 (HSD_STREX)
Reaction: EC: Evidence:
Physiological Direction:
androstan-3alpha,17beta-diol + NAD(+) = 17beta- hydroxyandrostanone + H(+) + NADH 1.1.1.53 -
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