Brand  (β version)

PDB ID: 1H48

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Ligands
Code Name Style Show Link
CDI 2c-methyl-D-erythritol 2,4-cyclodiphosphate PoSSuM
ZN Zinc ion PoSSuM
C5P Cytidine-5'-monophosphate PoSSuM
MN Manganese (II) ion PoSSuM
GPP Geranyl diphosphate PoSSuM
Non-standard Residues
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Structure summary

Code : 1H48   PDBj   RCSB PDB   PDBe
Header : SYNTHASE
Title : The structure of 2C-Methyl-D-erythritol 2,4-cyclodiphosphate synthase in complex with CMP and product
Release Data : 2004-12-22
Compound :
mol_id molecule chains synonym
1 2C-METHYL-D-ERYTHRITOL-2,4-CYCLODIPHOSPHATE SYNTHASE A,B,C,D,E,F MECPS, MECDP-SYNTHASE, ISPF, MECS
ec: 4.6.1.12
Source :
mol_id organism_scientific expression_system
1 ESCHERICHIA COLI  (taxid:511693) ESCHERICHIA COLI  (taxid:511693)
strain: BL21
expression_system_strain: BL21
expression_system_plasmid: PET15B
Authors : Kemp, L.E., Alphey, M.S., Bond, C.S., Hunter, W.N.
Keywords : SYNTHASE, ISOPRENOID, LYASE, ISOPRENE BIOSYNTHESIS
Exp. method : X-RAY DIFFRACTION ( 2.30 Å )
Citation :

The Identification of Isoprenoids that Bind in the Intersubunit Cavity of Escherichia Coli 2C-Methyl-D-Erythritol-2,4-Cyclodiphosphate Synthase by Complementary Biophysical Methods

Kemp, L.E.,Alphey, M.S.,Bond, C.S.  et al.
(2005)  Acta Crystallogr.,Sect.D  61 : 45

PubMed: 15608374
DOI: 10.1107/S0907444904025971

Reaction

Chain : A, B, C, D, E, F
UniProt : P36663 (ISPF_ECOLI)
Reaction: EC: Evidence:
Physiological Direction:
4-CDP-2-C-methyl-D-erythritol 2-phosphate = 2-C-methyl-D- erythritol 2,4-cyclic diphosphate + CMP 4.6.1.12 HAMAP-Rule:MF_00107, PubMed:10694574, PubMed:22839733
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4-CDP-2-C-methyl-D-erythritol = 2-C-methyl-D-erythritol 3,4- cyclophosphate + CMP + H(+) - PubMed:10694574
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