Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain:

Ligands
Code Name Link
FA6 3-hydroxyimino quinic acid
GOL Glycerol
SO4 Sulfate ion
Code : 1H0S
Header : LYASE
Title : 3-dehydroquinate dehydratase from Mycobacterium tuberculosis in complex with 3-hydroxyimino-quinic acid
Release Data : 2003-07-17
Compound :
mol_id molecule chains synonym
1 3-DEHYDROQUINATE DEHYDRATASE A 3-DEHYDROQUINASE, TYPE II DHQASE
ec: 4.2.1.10
Source :
mol_id organism_scientific expression_system
1 MYCOBACTERIUM TUBERCULOSIS  (taxid:83332) ESCHERICHIA COLI  (taxid:469008)
strain: H37RV
expression_system_strain: BL21(DE3)
expression_system_vector: PET-15B
expression_system_plasmid: MPET
Authors : Roszak, A.W., Frederickson, M., Abell, C., Coggins, J.R., Lapthorn, A.J.
Keywords : LYASE, SHIKIMATE PATHWAY, ALPHA/BETA PROTEIN
Exp. method : X-RAY DIFFRACTION ( 1.7 Å )
Citation :

Structural Basis for Specificity of Oxime Based Inhibitors Towards Type II Dehydroquinase from Mycobacterium Tuberculosis

Robinson, D.A.,Roszak, A.W.,Frederickson, M.  et al.
To be Published 

The Two Types of 3-Dehydroquinase Have Distinct Structures But Catalyze the Same Overall Reaction.

Gourley, D.G.,Shrive, A.K.,Polikarpov, I.  et al.
(1999)  Nat.Struct.Biol.  6 : 521

PubMed: 10360352
DOI: 10.1038/9287

Chain : A
UniProt : P0A4Z6 (multiple entry names are found)
Reaction : -