Brand  (β version)

PDB ID: 1GTE

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Ligands
Code Name Style Show Link
SF4 Iron/sulfur cluster PoSSuM
FMN Flavin mononucleotide PoSSuM
FAD Flavin-adenine dinucleotide PoSSuM
IUR 5-iodouracil PoSSuM
Non-standard Residues
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Structure summary

Code : 1GTE   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : DIHYDROPYRIMIDINE DEHYDROGENASE (DPD) FROM PIG, BINARY COMPLEX WITH 5-IODOURACIL
Release Data : 2002-04-11
Compound :
mol_id molecule chains synonym
1 DIHYDROPYRIMIDINE DEHYDROGENASE A,B,C,D DPD, DHPDHASE, DIHYDROURACIL DEHYDROGENASE, DIHYDROTHYMINE DEHYDROGENASE
ec: 1.3.1.2
Source :
mol_id organism_scientific organism_common expression_system
1 SUS SCROFA  (taxid:9823) PIG Escherichia coli DH5[alpha]  (taxid:668369)
organ: LIVER
expression_system_plasmid: PSE420
Authors : Dobritzsch, D., Ricagno, S., Schneider, G., Schnackerz, K.D., Lindqvist, Y.
Keywords : ELECTRON TRANSFER, FLAVIN, IRON-SULFUR CLUSTERS, PYRIMIDINE CATABOLISM, 5-FLUOROURACIL DEGRADATION, OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 1.65 Å )
Citation :

Crystal structure of the productive ternary complex of dihydropyrimidine dehydrogenase with NADPH and 5-iodouracil. Implications for mechanism of inhibition and electron transfer.

Dobritzsch, D.,Ricagno, S.,Schneider, G.  et al.
(2002)  J. Biol. Chem.  277 : 13155 - 13166

PubMed: 11796730
DOI: 10.1074/jbc.M111877200

Crystallization and Preliminary X-Ray Study of Pig Liver Dihydropyrimidine Dehydrogenase

Dobritzsch, D.,Persson, K.,Schneider, G.  et al.
(2001)  Acta Crystallogr.,Sect.D  57 : 153

PubMed: 11134942
DOI: 10.1107/S0907444900015250

Reaction

Chain : A, B, C, D
UniProt : Q28943 (DPYD_PIG)
Reaction: EC: Evidence:
Physiological Direction:
5,6-dihydrouracil + NADP(+) = H(+) + NADPH + uracil 1.3.1.2 PubMed:20831907, PubMed:8083224, PubMed:9860876
right-to-left PubMed:8083224
5,6-dihydrothymine + NADP(+) = H(+) + NADPH + thymine 1.3.1.2 PubMed:8083224
right-to-left