Het-PDB Navi2 (PDB: 1GRG)

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Ligands
Code	Name		Style	Show	Link
FAD	Flavin-adenine dinucleotide				PoSSuM
PO4	Phosphate ion				PoSSuM

Non-standard Residues
Code	Name	Show
0A8	S-[(2-chloroethyl)carbamoyl]-L-cysteine

Glycosylation
Code	Name	Emphasize

Modification
Code	Name	Show

Download interaction data: 1GRG

Code :

1GRG PDBj RCSB PDB PDBe

Header :

OXIDOREDUCTASE(FLAVOENZYME)

Title :

SUBSTRATE BINDING AND CATALYSIS BY GLUTATHIONE REDUCTASE AS DERIVED FROM REFINED ENZYME: SUBSTRATE CRYSTAL STRUCTURES AT 2 ANGSTROMS RESOLUTION

Release Data :

1994-01-31

Compound :

mol_id	molecule	chains
1	GLUTATHIONE REDUCTASE	A
	ec: 1.6.4.2

Source :

mol_id	organism_scientific	organism_common
1	Homo sapiens (taxid:9606)	Human

Authors :

Karplus, P.A., Schulz, G.E.

Keywords :

OXIDOREDUCTASE(FLAVOENZYME)

Exp. method :

X-RAY DIFFRACTION ( 2.0 Å )

Citation :

Substrate binding and catalysis by glutathione reductase as derived from refined enzyme: substrate crystal structures at 2 A resolution.

Karplus, P.A.,Schulz, G.E.
(1989) J.Mol.Biol. 210 : 163 - 180

PubMed: 2585516
DOI: 10.1016/0022-2836(89)90298-2

Inhibition of Human Glutathione Reductase by the Nitrosourea Drugs 1,3-Bis(2-Chloroethyl)-1-Nitrosourea and 1-(2-Chloroethyl)-3-(2-Hydroxyethyl)-1-Nitrosourea

Karplus, P.A.,Krauth-Siegel, R.L.,Schirmer, R.H. et al.
(1988) Eur.J.Biochem. 171 : 193

Refined Structure of Glutathione Reductase at 1.54 Angstroms Resolution

Karplus, P.A.,Schulz, G.E.
(1987) J.Mol.Biol. 195 : 701

Interaction of a Glutathione S-Conjugate with Glutathione Reductase. Kinetic and X-Ray Crystallographic Studies

Bilzer, M.,Krauth-Siegel, R.L.,Schirmer, R.H. et al.
(1984) Eur.J.Biochem. 138 : 373

Comparison of the Three-Dimensional Protein and Nucleotide Structure of the Fad-Binding Domain of P-Hydroxybenzoate Hydroxylase with the Fad-as Well as Nadph-Binding Domains of Glutathione Reductase

Wierenga, R.K.,Drenth, J.,Schulz, G.E.
(1983) J.Mol.Biol. 167 : 725

The Catalytic Mechanism of Glutathione Reductase as Derived from X-Ray Diffraction Analyses of Reaction Intermediates

Pai, E.F.,Schulz, G.E.
(1983) J.Biol.Chem. 258 : 1752

Fad-Binding Site of Glutathione Reductase

Schulz, G.E.,Schirmer, R.H.,Pai, E.F.
(1982) J.Mol.Biol. 160 : 287

Glutathione Reductase from Human Erythrocytes. The Sequences of the Nadph Domain and of the Interface Domain

Krauth-Siegel, R.L.,Blatterspiel, R.,Saleh, M. et al.
(1982) Eur.J.Biochem. 121 : 259

Three-Dimensional Structure of Glutathione Reductase at 2 Angstroms Resolution

Thieme, R.,Pai, E.F.,Schirmer, R.H. et al.
(1981) J.Mol.Biol. 152 : 763

Gene Duplication in Glutathione Reductase

Schulz, G.E.
(1980) J.Mol.Biol. 138 : 335

The C-Terminal Fragment of Human Glutathione Reductase Contains the Postulated Catalytic Histidine

Untucht-Grau, R.,Schulz, G.E.,Schirmer, R.H.
(1979) FEBS Lett. 105 : 244

The Structure of the Flavoenzyme Glutathione Reductase

Schulz, G.E.,Schirmer, R.H.,Sachsenheimer, W. et al.
(1978) Nature 273 : 120

Low Resolution Structure of Human Erythrocyte Glutathione Reductase

Zappe, H.A.,Krohne-Ehrich, G.,Schulz, G.E.
(1977) J.Mol.Biol. 113 : 141

Crystals of Human Erythrocyte Glutathione Reductase

Schulz, G.E.,Zappe, H.,Worthington, D.J. et al.
(1975) FEBS Lett. 54 : 86

Chain :

UniProt :

P00390 (GSHR_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
2 glutathione + NADP(+) = glutathione disulfide + H(+) + NADPH	1.8.1.7	PubMed:17185460
	-	PubMed:17185460

PDB ID: 1GRG

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