Brand  (β version)

PDB ID: 1FV3

Hetero Atom Contents

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
CEQ Ethyl-trimethyl-silane PoSSuM
BGC Beta-D-glucopyranose PoSSuM
GAL Beta-D-galactopyranose PoSSuM
NGA 2-acetamido-2-deoxy-beta-D-galactopyranose PoSSuM
SIA N-acetyl-alpha-neuraminic acid PoSSuM
SLB N-acetyl-beta-neuraminic acid PoSSuM
: Polysaccharide
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 1FV3   PDBj   RCSB PDB   PDBe
Header : TOXIN
Title : THE HC FRAGMENT OF TETANUS TOXIN COMPLEXED WITH AN ANALOGUE OF ITS GANGLIOSIDE RECEPTOR GT1B
Release Data : 2001-09-05
Compound :
mol_id molecule chains
1 TETANUS TOXIN HEAVY CHAIN A,B
fragment: C-TERMINAL DOMAIN OF HEAVY CHAIN
Source :
mol_id organism_scientific expression_system
1 Clostridium tetani  (taxid:1513) Escherichia coli  (taxid:562)
expression_system_plasmid: PET28
Authors : Fotinou, C., Emsley, P., Black, I., Ando, H., Ishida, H., Kiso, M., Sinha, K.A., Fairweather, N.F., Isaacs, N.W.
Keywords : toxin, carbohydrate, ganglioside, multi-valent binding, receptor
Exp. method : X-RAY DIFFRACTION ( 2.30 Å )
Citation :

The crystal structure of tetanus toxin Hc fragment complexed with a synthetic GT1b analogue suggests cross-linking between ganglioside receptors and the toxin.

Fotinou, C.,Emsley, P.,Black, I.  et al.
(2001)  J.Biol.Chem.  276 : 32274 - 32281

PubMed: 11418600
DOI: 10.1074/jbc.M103285200

The Structures of the HC Fragment of Tetanus Toxin with Carbohydrate Subunit Complexes Provide Insight into Ganglioside Binding

Emsley, P.,Fotinou, C.,Black, I.  et al.
(2000)  J.Biol.Chem.  275 : 8889 - 8894

DOI: 10.1074/jbc.275.12.8889

Structure of the receptor binding fragment Hc of tetanus neurotoxin

Umland, T.C.,Wingert, L.M.,Swaminathan, S.  et al.
(1997)  Nat.Struct.Biol.  4 : 788 - 792

Reaction

Chain : A, B
UniProt : P04958 (TETX_CLOTE)
Reaction: EC: Evidence:
Physiological Direction:
Hydrolysis of 76-Gln-|-Phe-77 bond in synaptobrevin 2. 3.4.24.68 -
-