Brand  (β version)

PDB ID: 1EWP

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Ligands
Code Name Style Show Link
0I5 N-[(3s)-1-fluoro-2-oxo-5-phenylpentan-3-yl]-N~2~-(morpholin-4-ylcarbonyl)-L-leucinamide PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1EWP   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE inhibitor
Title : CRUZAIN BOUND TO MOR-LEU-HPQ
Release Data : 2000-05-17
Compound :
mol_id molecule chains synonym
1 CRUZAIN A CRUZIPAIN, CRUZAINE
ec: 3.4.22.-
fragment: CATALYTIC DOMAIN
Source :
mol_id organism_scientific expression_system
1 Trypanosoma cruzi  (taxid:5693) Escherichia coli  (taxid:562)
expression_system_strain: DH5ALPHA
expression_system_plasmid: CHEY
Authors : Gillmor, S.A.
Keywords : cysteine protease, drug design, covalent inhibitor, cruzipain, HYDROLASE, HYDROLASE-HYDROLASE inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 1.75 Å )
Citation :

Chapter 3: X-ray Structures of Complexes of Cruzain with Designed Covalent Inhibitors

Gillmor, S.A.
(1998)  Enzyme-ligand Interactions, Inhibition and Specificity  : 50 - 80

PubMed: -1

Structural Determinants of Specificity in the Cysteine Protease Cruzain

Gillmor, S.A.,Craik, C.S.,Fletterick, R.J.
(1997)  Protein Sci.  6 : 1603 - 1611

The Crystal Structure of Cruzain: a Therapeutic Target for Chagas' Disease

McGrath, M.E.,Eakin, A.E.,Engel, J.C.  et al.
(1995)  J.Mol.Biol.  247 : 251 - 259

DOI: 10.1006/jmbi.1994.0137

Reaction

Chain : A
UniProt : P25779 (CYSP_TRYCR)
Reaction: EC: Evidence:
Physiological Direction:
Broad endopeptidase specificity similar to that of cathepsin L. 3.4.22.51 -
-