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Ligands
Code Name Style Show Link
0Z0 N-(trifluoroacetyl)-L-phenylalanyl-N-[4-(trifluoromethyl)phenyl]-L-alaninamide
ACY Acetic acid
CA Calcium ion
Non-standard Residues
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Glycosylation
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Code : 1ELD   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : Structural analysis of the active site of porcine pancreatic elastase based on the X-ray crystal structures of complexes with trifluoroacetyl-dipeptide-anilide inhibitors
Release Data : 1995-02-14
Compound :
mol_id molecule chains
1 ELASTASE E
ec: 3.4.21.36
Source :
mol_id organism_scientific organism_common
1 Sus scrofa  (taxid:9823) Pig
organ: PANCREAS
Authors : Mattos, C., Petsko, G.A., Ringe, D.
Keywords : HYDROLASE-HYDROLASE INHIBITOR COMPLEX, SERINE PROTEINASE
Exp. method : X-RAY DIFFRACTION ( 2. Å )
Citation :

Structural analysis of the active site of porcine pancreatic elastase based on the X-ray crystal structures of complexes with trifluoroacetyl-dipeptide-anilide inhibitors.

Mattos, C.,Giammona, D.A.,Petsko, G.A.  et al.
(1995)  Biochemistry  34 : 3193 - 3203

PubMed: 7880814
DOI: 10.1021/bi00010a008

Analogous Inhibitors of Elastase Do not Always Bind Analogously

Mattos, C.,Rasmussen, B.,Ding, X.  et al.
(1994)  Nat.Struct.Biol.  1 : 55

Interaction of the Peptide Cf3-Leu-Ala-Nh-C6H4-Cf3(Tfla) with Porcine Pancreatic Elastase. X-Ray Studies at 1.8 Angstroms

Li De La Sierra, I.,Papamichael, E.,Sakarelos, C.  et al.
(1990)  J.Mol.Recog.  3 : 36

Structure of Native Porcine Pancreatic Elastase at 1.65 Angstroms Resolution

Meyer, E.,Cole, G.,Radhakrishnan, R.  et al.
(1988)  Acta Crystallogr.,Sect.B  44 : 26

Structure of the Product Complex of Acetyl-Ala-Pro-Ala with Porcine Pancreatic Elastase at 1.65 Angstroms Resolution

Meyer, E.,Radhakrishnan, R.,Cole, G.  et al.
(1986)  J.Mol.Biol.  189 : 533

Crystallographic Study of the Binding of a Tri-Fluoroacetyl Dipeptide Anilide Inhibitor with Elastase

Hughes, D.L.,Diecker, L.C.,Bieth, L.C.  et al.
(1982)  J.Mol.Biol.  162 : 645

The Indirect Mechanism of Action of the Trifluoroacetyl Peptides on Elastase

Dimicoli, J.-L.,Renaud, A.,Bieth, J.
(1980)  Eur.J.Biochem.  107 : 423

The Atomic Structure of Crystalline Porcine Pancreatic Elastase at 2.5 Angstroms Resolution. Comparisons with the Structure of Alpha-Chymotrypsin

Sawyer, L.,Shotton, C.M.,Campbell, J.W.  et al.
(1978)  J.Mol.Biol.  118 : 137

Chain : E
UniProt : P00772 (CELA1_PIG)
Reaction: EC: Evidence:
Physiological Direction:
Hydrolysis of proteins, including elastin. Preferential cleavage: Ala-|-Xaa. 3.4.21.36 PubMed:5415108
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