Brand  (β version)

PDB ID: 1E1V

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Ligands
Code Name Style Show Link
CMG 6-O-cyclohexylmethyl guanine PoSSuM
Non-standard Residues
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Glycosylation
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Modification
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ACE Acetyl group

Structure summary

Code : 1E1V   PDBj   RCSB PDB   PDBe
Header : PROTEIN KINASE
Title : HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR NU2058
Release Data : 2001-05-10
Compound :
mol_id molecule chains synonym
1 CYCLIN-DEPENDENT PROTEIN KINASE 2 A CDK2
ec: 2.7.1.37
other_details: COMPLEX WITH CYCLIN A OR CYCLIN E
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN SPODOPTERA FRUGIPERDA  (taxid:7108)
expression_system_cell_line: SF9
expression_system_vector_type: BACULOVIRUS
Authors : Endicott, J.A., Noble, M.E.M., Johnson, L.N.
Keywords : PROTEIN KINASE, CELL CYCLE, PHOSPHORYLATION, CELL DIVISION, MITOSIS, INHIBITION
Exp. method : X-RAY DIFFRACTION ( 1.95 Å )
Citation :

Identification of Novel Purine and Pyrimidine Cyclin-Dependent Kinase Inhibitors with Distinct Molecular Interactions and Tumor Cell Growth Inhibition Profiles.

Arris, C.E.,Boyle, F.T.,Calvert, A.H.  et al.
(2000)  J.Med.Chem.  43 : 2797

PubMed: 10956187
DOI: 10.1021/JM990628O

Reaction

Chain : A
UniProt : P24941 (CDK2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.22 PubMed:1396589, PubMed:28666995, PubMed:9030781
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ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.22 PubMed:1396589, PubMed:28666995, PubMed:9030781
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