Brand  (β version)

PDB ID: 1DJW

Hetero Atom Contents

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
CA Calcium ion PoSSuM
ACT Acetate ion PoSSuM
CIP Inositol-2-methylene-1,2-cyclic-monophosphate PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 1DJW   PDBj   RCSB PDB   PDBe
Header : LIPID DEGRADATION
Title : PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C-DELTA1 FROM RAT COMPLEXED WITH INOSITOL-2-METHYLENE-1,2-CYCLIC-MONOPHOSPHONATE
Release Data : 1997-07-23
Compound :
mol_id molecule chains synonym
1 PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C, ISOZYME DELTA1 A,B PLC-D1
ec: 3.1.4.11
mutation: DELTA(1-132) DELETION VARIANT
other_details: CATALYTICALLY-ACTIVE DELETION VARIANT THAT LACKS AN N-TERMINAL PH DOMAIN, COMPLEXED WITH INOSITOL-2-METHYLENE-1,2-CYCLIC-MONOPHOSPHONATE
Source :
mol_id organism_scientific organism_common expression_system
1 Rattus norvegicus  (taxid:10116) Norway rat Escherichia coli  (taxid:562)
gene: CDNA FRAGMENT
expression_system_plasmid: PGEX (PHARMACIA)
expression_system_gene: CDNA FRAGMENT
Authors : Essen, L.-O., Perisic, O., Williams, R.L.
Keywords : PHOSPHORIC DIESTER HYDROLASE, HYDROLASE, LIPID DEGRADATION, TRANSDUCER, CALCIUM-BINDING, PHOSPHOLIPASE C, PHOSPHOINOSITIDE-SPECIFIC
Exp. method : X-RAY DIFFRACTION ( 2.45 Å )
Citation :

Structural mapping of the catalytic mechanism for a mammalian phosphoinositide-specific phospholipase C.

Essen, L.O.,Perisic, O.,Katan, M.  et al.
(1997)  Biochemistry  36 : 1704 - 1718

PubMed: 9048554
DOI: 10.1021/bi962512p

Crystal Structure of a Mammalian Phosphoinositide-Specific Phospholipase C Delta

Essen, L.O.,Perisic, O.,Cheung, R.  et al.
(1996)  Nature  380 : 595

Reaction

Chain : A, B
UniProt : P10688 (PLCD1_RAT)
Reaction: EC: Evidence:
Physiological Direction:
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5- bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2- diacyl-sn-glycerol + H(+) 3.1.4.11 PubMed:16000311
left-to-right
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+) - UniProtKB:P51178
left-to-right