Het-PDB Navi2 (PDB: 1DIT)

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Ligands
Code	Name		Style	Show	Link

Non-standard Residues
Code	Name	Show
0MG	Amino{[(4s)-4-amino-5-carboxy-5-oxopentyl]amino}methaniminium

Glycosylation
Code	Name	Emphasize

Modification
Code	Name	Show
2PP	2-propyl-pentanoic acid

Download interaction data: 1DIT

Code :

1DIT PDBj RCSB PDB PDBe

Header :

HYDROLASE/HYDROLASE INHIBITOR

Title :

COMPLEX OF A DIVALENT INHIBITOR WITH THROMBIN

Release Data :

1996-06-10

Compound :

mol_id	molecule	chains
1	ALPHA-THROMBIN	L
	ec: 3.4.21.5

mol_id	molecule	chains
2	ALPHA-THROMBIN	H
	ec: 3.4.21.5

mol_id	molecule	chains
3	PEPTIDE INHIBITOR CVS995	P

Source :

mol_id	organism_scientific	organism_common
1	Homo sapiens (taxid:9606)	Human

mol_id	organism_scientific	organism_common
2	Homo sapiens (taxid:9606)	Human

mol_id	organism_scientific
3

Authors :

Tulinsky, A., Krishnan, R.

Keywords :

HYDROLASE, BLOOD COAGULATION, INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX

Exp. method :

X-RAY DIFFRACTION ( 2.3 Å )

Citation :

Synthesis, structure, and structure-activity relationships of divalent thrombin inhibitors containing an alpha-keto-amide transition-state mimetic.

Krishnan, R.,Tulinsky, A.,Vlasuk, G.P. et al.
(1996) Protein Sci. 5 : 422 - 433

PubMed: 8868478

Structure of the Hirulog 3-Thrombin Complex and Nature of the S' Subsites of Substrates and Inhibitors

Qiu, X.,Padmanabhan, K.P.,Carperos, V.E. et al.
(1992) Biochemistry 31 : 11689

Structure of the Hirugen and Hirulog 1 Complexes of Alpha-Thrombin

Skrzypczak-Jankun, E.,Carperos, V.E.,Ravichandran, K.G. et al.
(1991) J.Mol.Biol. 221 : 1379

Refined Structure of the Hirudin-Thrombin Complex

Rydel, T.J.,Tulinsky, A.,Bode, W. et al.
(1991) J.Mol.Biol. 221 : 583

PDB ID: 1DIT

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