Het-PDB Navi2 (PDB: 1BZH)

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Ligands
Code	Name		Style	Show	Link

Non-standard Residues
Code	Name	Show
AEA	(2-amino-2-carbamoyl-ethylsulfanyl)-acetic acid
FLT	Fluoromalonyl tyrosine

Glycosylation
Code	Name	Emphasize

Modification
Code	Name	Show

Download interaction data: 1BZH

Code :

1BZH PDBj RCSB PDB PDBe

Header :

HYDROLASE/HYDROLASE INHIBITOR

Title :

Cyclic peptide inhibitor of human PTP1B

Release Data :

1999-02-16

Compound :

mol_id	molecule	chains	synonym
1	PROTEIN (PROTEIN-TYROSINE-PHOSPHATASE 1B)	A	PTP1B
	ec: 3.1.3.48 fragment: CATALYTIC DOMAIN

mol_id	molecule	chains
2	PROTEIN (PROTEIN-TYROSINE-PHOSPHATASE 1B INHIBITOR)	I

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)

mol_id	organism_scientific	organism_common	expression_system
2	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)

Authors :

Groves, M.R., Yao, Z.J., Burke Jr., T.R., Barford, D.

Keywords :

PHOSPHORYLATION-INHIBITOR COMPLEX, TYROSINE PHOSPHATASE, HYDROLASE-HYDROLASE INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 2.1 Å )

Citation :

Structural basis for inhibition of the protein tyrosine phosphatase 1B by phosphotyrosine peptide mimetics.

Groves, M.R.,Yao, Z.J.,Roller, P.P. et al.
(1998) Biochemistry 37 : 17773 - 17783

Crystal Structure of Human Protein Tyrosine Phosphatase 1B

Barford, D.,Flint, A.J.,Tonks, N.K.
(1994) Science 263 : 1397 - 1404

Chain :

UniProt :

P18031 (PTN1_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate	3.1.3.48	PROSITE- ProRule:PRU10044
	-	PROSITE- ProRule:PRU10044

PDB ID: 1BZH