Brand  (β version)

PDB ID: 1BZH

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Ligands
Code Name Style Show Link
Non-standard Residues
Code Name Show
AEA (2-amino-2-carbamoyl-ethylsulfanyl)-acetic acid
FLT Fluoromalonyl tyrosine
Glycosylation
Code Name Emphasize
Modification
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Structure summary

Code : 1BZH   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : Cyclic peptide inhibitor of human PTP1B
Release Data : 1999-02-16
Compound :
mol_id molecule chains synonym
1 PROTEIN (PROTEIN-TYROSINE-PHOSPHATASE 1B) A PTP1B
ec: 3.1.3.48
fragment: CATALYTIC DOMAIN
mol_id molecule chains
2 PROTEIN (PROTEIN-TYROSINE-PHOSPHATASE 1B INHIBITOR) I
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
mol_id organism_scientific organism_common expression_system
2 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
Authors : Groves, M.R., Yao, Z.J., Burke Jr., T.R., Barford, D.
Keywords : PHOSPHORYLATION-INHIBITOR COMPLEX, TYROSINE PHOSPHATASE, HYDROLASE-HYDROLASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.1 Å )
Citation :

Structural basis for inhibition of the protein tyrosine phosphatase 1B by phosphotyrosine peptide mimetics.

Groves, M.R.,Yao, Z.J.,Roller, P.P.  et al.
(1998)  Biochemistry  37 : 17773 - 17783

PubMed: 9922143
DOI: 10.1021/bi9816958

Crystal Structure of Human Protein Tyrosine Phosphatase 1B

Barford, D.,Flint, A.J.,Tonks, N.K.
(1994)  Science  263 : 1397 - 1404

Reaction

Chain : A
UniProt : P18031 (PTN1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate 3.1.3.48 PROSITE-ProRule:PRU10044
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