Brand  (β version)

PDB ID: 1BOA

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Ligands
Code Name Style Show Link
CO Cobalt (II) ion PoSSuM
FUG Fumagillin PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1BOA   PDBj   RCSB PDB   PDBe
Header : AMINOPEPTIDASE
Title : HUMAN METHIONINE AMINOPEPTIDASE 2 COMPLEXED WITH ANGIOGENESIS INHIBITOR FUMAGILLIN
Release Data : 1999-08-01
Compound :
mol_id molecule chains
1 METHIONINE AMINOPEPTIDASE A
ec: 3.4.11.18
other_details: COMPLEX WITH FUMAGILLIN AND COBALT
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
cellular_location: CYTOPLASM
expression_system_common: Fall armyworm
expression_system_cell_line: SF21 CELLS
expression_system_vector: BACULOVIRUS, PACSG2
Authors : Liu, S., Widom, J., Kemp, C.W., Crews, C.M., Clardy, J.C.
Keywords : METHIONINE AMINOPEPTIDASE, ANGIOGENESIS INHIBITOR, FUMAGILLIN, HYDROLASE, AMINOPEPTIDASE
Exp. method : X-RAY DIFFRACTION ( 1.8 Å )
Citation :

Structure of human methionine aminopeptidase-2 complexed with fumagillin.

Liu, S.,Widom, J.,Kemp, C.W.  et al.
(1998)  Science  282 : 1324 - 1327

PubMed: 9812898
DOI: 10.1126/science.282.5392.1324

Reaction

Chain : A
UniProt : P50579 (MAP2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides. 3.4.11.18 HAMAP-Rule:MF_03175, PubMed:20521764
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