Brand  (β version)

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Ligands
Code Name Style Show Link
CND 5-beta-D-ribofuranosylnicotinamide adenine dinucleotide
EOH Ethanol
ZN Zinc ion
Non-standard Residues
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Glycosylation
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Modification
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Code : 1ADB   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE (NAD(A)-CHOH(D))
Title : CRYSTALLOGRAPHIC STUDIES OF ISOSTERIC NAD ANALOGUES BOUND TO ALCOHOL DEHYDROGENASE: SPECIFICITY AND SUBSTRATE BINDING IN TWO TERNARY COMPLEXES
Release Data : 1995-06-03
Compound :
mol_id molecule chains
1 ALCOHOL DEHYDROGENASE A,B
ec: 1.1.1.1
Source :
mol_id organism_scientific organism_common
1 Equus caballus  (taxid:9796) Horse
Authors : Li, H., Hallows, W.A., Punzi, J.S., Pankiewicz, K.W., Watanabe, K.A., Goldstein, B.M.
Keywords : OXIDOREDUCTASE (NAD(A)-CHOH(D))
Exp. method : X-RAY DIFFRACTION ( 2.4 Å )
Citation :

Crystallographic studies of isosteric NAD analogues bound to alcohol dehydrogenase: specificity and substrate binding in two ternary complexes.

Li, H.,Hallows, W.H.,Punzi, J.S.  et al.
(1994)  Biochemistry  33 : 11734 - 11744

PubMed: 7918390
DOI: 10.1021/bi00205a009

Interdomain Motion in Liver Alcohol Dehydrogenase. Structural and Energetic Analysis of the Hinge Bending Mode

Colonna-Cesari, F.,Perahia, D.,Karplus, M.  et al.
(1986)  J.Biol.Chem.  261 : 15273

Crystallographic Investigations of Nicotinamide Adenine Dinucleotide Binding to Horse Liver Alcohol Dehydrogenase

Eklund, H.,Samama, J.-P.,Jones, T.A.
(1984)  Biochemistry  23 : 5982

Crystal Structures of the Active Site in Specifically Metal-Depleted and Cobalt-Substituted Horse Liver Alcohol Dehydrogenase Derivatives

Schneider, G.,Eklund, H.,Cedergren-Zeppezauer, E.  et al.
(1983)  Proc.Natl.Acad.Sci.USA  80 : 5289

Three-Dimensional Structure of Isonicotinimidylated Liver Alcohol Dehydrogenase

Plapp, B.V.,Eklund, H.,Jones, T.A.  et al.
(1983)  J.Biol.Chem.  258 : 5537

Crystal-Structure Determination of Reduced Nicotinamide Adenine Dinucleotide Complex with Horse Liver Alcohol Dehydrogenase Maintained in its Apo Conformation by Zinc-Bound Imidazole

Cedergren-Zeppezauer, E.
(1983)  Biochemistry  22 : 5761

Binding of Substrate in a Ternary Complex of Horse Liver Alcohol Dehydrogenase

Eklund, H.,Plapp, B.V.,Samama, J.-P.  et al.
(1982)  J.Biol.Chem.  257 : 14349

Crystal Structure Determinations of Coenzyme Analogue and Substrate Complexes of Liver Alcohol Dehydrogenase. Binding of 1,4,5,6-Tetrahydronicotinamide Adenine Dinucleotide and Trans-4-(N,N-Dimethylamino)Cinnamaldehyde to the Enzyme

Cedergren-Zeppezauer, E.,Samama, J.-P.,Eklund, H.
(1982)  Biochemistry  21 : 4895

Pyrazole Binding in Crystalline Binary and Ternary Complexes with Liver Alcohol Dehydrogenase

Eklund, H.,Samama, J.-P.,Wallen, L.
(1982)  Biochemistry  21 : 4858

5-Methylnicotinamide-Adenine Dinucleotide. Kinetic Investigation with Major and Minor Isoenzymes of Liver Alcohol Dehydrogenase and Structural Determination of its Binary Complex with Alcohol Dehydrogenase

Samama, J.-P.,Wrixon, A.D.,Biellmann, J.-F.
(1981)  Eur.J.Biochem.  118 : 479

Structural Differences between Apo-and Holoenzyme of Horse Liver Alcohol Dehydrogenase

Eklund, H.,Branden, C.-I.
(1979)  J.Biol.Chem.  254 : 3458

X-Ray Studies of the Binding of Cibacron Blue F3Ga to Liver Alcohol Dehydrogenase

Biellmann, J.-F.,Samama, J.-P.,Branden, C.I.  et al.
(1979)  Eur.J.Biochem.  102 : 107

Crystallography of Liver Alcohol Dehydrogenase Complexed with Substrates

Plapp, B.V.,Eklund, H.,Branden, C.-I.
(1978)  J.Mol.Biol.  122 : 23

Crystallization of Liver Alcohol Dehydrogenase Activated by the Modification of Amino Groups

Plapp, B.V.,Zeppezauer, E.,Branden, C.-I.
(1978)  J.Mol.Biol.  119 : 451

Subunit Conformation of Yeast Alcohol Dehydrogenase

Jornvall, H.,Eklund, H.,Branden, C.-I.
(1978)  J.Biol.Chem.  253 : 8414

The Crystal Structure of Complexes between Horse Liver Alcohol Dehydrogenase and the Coenzyme Analogues 3-Iodopyridine-Adenine Dinucleotide and Pyridine-Adenine Dinucleotide

Samama, J.-P.,Zeppezauer, E.,Biellmann, J.-F.  et al.
(1977)  Eur.J.Biochem.  81 : 403

X-Ray Investigation of the Binding of 1,10-Phenanthroline and Imidazole to Horse-Liver Alcohol Dehydrogenase

Boiwe, T.,Branden, C.-I.
(1977)  Eur.J.Biochem.  77 : 173

Three-Dimensional Structure of Horse Liver Alcohol Dehydrogenase at 2.4 Angstroms Resolution

Eklund, H.,Nordstrom, B.,Zeppezauer, E.  et al.
(1976)  J.Mol.Biol.  102 : 27

Structural Comparisons of Mammalian, Yeast and Bacillar Alcohol Dehydrogenases

Eklund, H.,Branden, C.-I.,Jornvall, H.
(1976)  J.Mol.Biol.  102 : 61

The Binding of Nucleotides to Horse Liver Alcohol Dehydrogenase

Nordstrom, B.,Branden, C.-I.
(1975)  STRUCTURE AND CONFORMATION OF NUCLEIC ACIDS AND PROTEIN-NUCLEIC ACID INTERACTIONS : PROCEEDINGS OF THE FOURTH ANNUAL HARRY STEENBOCK SYMPOSIUM, JUNE 16-19, 1974, MADISON, WISCONSIN  : 387

Alcohol Dehydrogenases

Branden, C.-I.,Jornvall, H.,Eklund, H.  et al.
(1975)  The Enzymes,Third Edition  11 : 103

The Conformation of Adenosine Diphosphoribose and 8-Bromoadenosine Diphosphoribose When Bound to Liver Alcohol Dehydrogenase

Abdallah, M.A.,Biellmann, J.-F.,Nordstrom, B.  et al.
(1975)  Eur.J.Biochem.  50 : 475

The Structure of Horse Liver Alcohol Dehydrogenase

Eklund, H.,Nordstrom, B.,Zeppezauer, E.  et al.
(1974)  FEBS Lett.  44 : 200

Structural and Functional Similarities within the Coenzyme Binding Domains of Dehydrogenases

Ohlsson, I.,Nordstrom, B.,Branden, C.-I.
(1974)  J.Mol.Biol.  89 : 339

Binding of Salicylate in the Adenosine-Binding Pocket of Dehydrogenases

Einarsson, R.,Eklund, H.,Zeppezauer, E.  et al.
(1974)  Eur.J.Biochem.  49 : 41

Structure of Liver Alcohol Dehydrogenase at 2.9-Angstrom Resolution

Branden, C.-I.,Eklund, H.,Nordstrom, B.  et al.
(1973)  Proc.Natl.Acad.Sci.USA  70 : 2439

Structure of Horse Liver Alcohol Dehydrogenase. I. Structural Symmetry and Conformational Changes

Branden, C.-I.
(1965)  Arch.Biochem.Biophys.  112 : 215

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(1972)  Atlas of Protein Sequence and Structure (Data Section)  5 : 145

Chain : A, B
UniProt : P00327 (ADH1E_HORSE)
Reaction: EC: Evidence:
Physiological Direction:
a primary alcohol + NAD(+) = an aldehyde + H(+) + NADH 1.1.1.1 -
-
a secondary alcohol + NAD(+) = a ketone + H(+) + NADH 1.1.1.1 -
-