Brand  (β version)

PDB ID: 1ZZZ

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Ligands
Code Name Style Show Link
0IV 2-{(3s)-3-[(benzylsulfonyl)amino]-2-oxopiperidin-1-yl}-N-{(2s)-1-[(3r)-1-carbamimidoylpiperidin-3-yl]-3-oxopropan-2-yl}acetamide PoSSuM
CA Calcium ion PoSSuM
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Structure summary

Code : 1ZZZ   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : Trypsin inhibitors with rigid tripeptidyl aldehydes
Release Data : 1999-06-15
Compound :
mol_id molecule chains synonym
1 TRYPSIN A TRP-CVS1694
Source :
mol_id organism_scientific organism_common
1 Bos taurus  (taxid:9913) Cattle
Authors : Krishnan, R., Zhang, E., Hakansson, K., Arni, R.K., Tulinsky, A., Lim-Wilby, M.S.L., Levy, O.E., Semple, J.E., Brunck, T.K.
Keywords : SERINE PROTEASE, HYDROLASE-HYDROLASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 1.9 Å )
Citation :

Highly selective mechanism-based thrombin inhibitors: structures of thrombin and trypsin inhibited with rigid peptidyl aldehydes.

Krishnan, R.,Zhang, E.,Hakansson, K.  et al.
(1998)  Biochemistry  37 : 12094 - 12103

PubMed: 9724521
DOI: 10.1021/bi980840e

Reaction

Chain : A
UniProt : P00760 (TRY1_BOVIN)
Reaction: EC: Evidence:
Physiological Direction:
Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa. 3.4.21.4 -
-
Cofactor: Evidence: Note:
Ca(2+) - Binds 1 Ca(2+) ion per subunit.