Brand  (β version)

PDB ID: 1ZX1

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Ligands
Code Name Style Show Link
CB1 5-(aziridin-1-yl)-2,4-dinitrobenzamide PoSSuM
FAD Flavin-adenine dinucleotide PoSSuM
ZN Zinc ion PoSSuM
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Structure summary

Code : 1ZX1   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Human quinone oxidoreductase 2 (NQO2) in complex with the cytostatic prodrug CB1954
Release Data : 2005-06-14
Compound :
mol_id molecule chains synonym
1 NRH dehydrogenase [quinone] 2 A,B Quinone reductase 2, QR2, NRH:quinone oxidoreductase 2
ec: 1.6.99.-
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
gene: NQO2, NMOR2
expression_system_strain: BL21DE3
expression_system_vector_type: p11
expression_system_plasmid: NQO2A-c001
Authors : Jansson, A., Wu, X., Kavanagh, K., Kerr, D., Knox, R., Walton, R., Gunther, U., Ludwig, C., Edwards, A., Arrowsmith, C., Sundstrom, M., von Delft, F., Oppermann, U., Structural Genomics Consortium (SGC)
Keywords : Quinone oxidoreductase 2, reductions of quinones, dihydronicotinamide ribose, electrondonor, 5-(aziridin-1-yl)-2, 4-dinitrobenamide (CB1954), flavin-containing, Structural Genomics, Structural Genomics Consortium, SGC, oxidoreductase
Exp. method : X-RAY DIFFRACTION ( 2.16 Å )
Citation :

Human quinone oxidoreductase 2 (NQO2) in complex with the cytostatic prodrug CB1954

Jansson, A.,Wu, X.,Kavanagh, K.  et al.
To be Published 

Reaction

Chain : A, B
UniProt : P16083 (NQO2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone + H(+) = a quinol + beta-nicotinamide D-riboside 1.10.5.1 PubMed:18579530
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