Brand  (β version)

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Ligands
Code Name Style Show Link
CB5 Cobalt bis(1,2-dicarbollide)
Non-standard Residues
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Glycosylation
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Code : 1ZTZ   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Crystal structure of HIV protease- metallacarborane complex
Release Data : 2005-11-01
Compound :
mol_id molecule chains synonym
1 PROTEASE RETROPEPSIN A,B HIV-1 PROTEASE
ec: 3.4.23.16
mutation: Q7K, L33I, L63I
mol_id molecule chains
2 autoproteolytic tetrapeptide P
Source :
mol_id organism_scientific expression_system
1 Human immunodeficiency virus 1  (taxid:11676) Escherichia coli BL21(DE3)  (taxid:469008)
gene: gag-pol
expression_system_strain: BL21 (DE3)
expression_system_vector_type: PLASMID
expression_system_plasmid: pET like, T7 promotor driven
mol_id organism_scientific
2
synthetic: yes
Authors : Cigler, P., Kozisek, M., Rezacova, P., Brynda, J., Otwinowski, Z., Sedlacek, J., Bodem, J., Kraeusslich, H.-G., Kral, V., Konvalinka, J.
Keywords : rational drug design; HIV protease inhibitors; aspartic proteases; carboranes; metallacarboranes, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 2.15 Å )
Citation :

From nonpeptide toward noncarbon protease inhibitors: Metallacarboranes as specific and potent inhibitors of HIV protease

Cigler, P.,Kozisek, M.,Rezacova, P.  et al.
(2005)  Proc.Natl.Acad.Sci.USA  102 : 15394 - 15399

PubMed: 16227435
DOI: 10.1073/pnas.0507577102

Chain : A, B
UniProt : P03367 (POL_HV1BR)
Reaction: EC: Evidence:
Physiological Direction:
Specific for a P1 residue that is hydrophobic, and P1' variable, but often Pro. 3.4.23.16 PROSITE-ProRule:PRU00275
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Endohydrolysis of RNA in RNA/DNA hybrids. Three different cleavage modes: 1. sequence-specific internal cleavage of RNA. Human immunodeficiency virus type 1 and Moloney murine leukemia virus enzymes prefer to cleave the RNA strand one nucleotide away from the RNA-DNA junction. 2. RNA 5'-end directed cleavage 13-19 nucleotides from the RNA end. 3. DNA 3'-end directed cleavage 15-20 nucleotides away from the primer terminus. 3.1.26.13 -
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3'-end directed exonucleolytic cleavage of viral RNA-DNA hybrid. 3.1.13.2 -
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a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1) 2.7.7.49 PROSITE- ProRule:PRU00405
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a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1) 2.7.7.7 PROSITE- ProRule:PRU00405
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