PDB ID: 1ZSF
Hetero Atom Contents
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Structure summary
Code : | 1ZSF | ||||||||||||
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Header : | HYDROLASE/HYDROLASE INHIBITOR | ||||||||||||
Title : | Crystal Structure of Complex of a Hydroxyethylamine Inhibitor with HIV-1 Protease at 2.0A Resolution | ||||||||||||
Release Data : | 2006-04-25 | ||||||||||||
Compound : |
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Source : |
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Authors : | Duskova, J., Skalova, T., Dohnalek, J., Petrokova, H., Hasek, J. | ||||||||||||
Keywords : | HIV, PROTEASE, PEPTIDOMIMETIC INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 1.98 Å ) | ||||||||||||
Citation : |
On the role of the R configuration of the reaction-intermediate isostere in HIV-1 protease-inhibitor binding: X-ray structure at 2.0 A resolution.
Duskova, J.,Dohnalek, J.,Skalova, T.
et al.
PubMed: 16627941 |
Reaction
Chain : | A, B |
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UniProt : | P03367 (POL_HV1BR) |
Reaction : | Specific for a P1 residue that is hydrophobic, and P1' variable, but often Pro. Endohydrolysis of RNA in RNA/DNA hybrids. Three different cleavage modes: 1. sequence-specific internal cleavage of RNA. Human immunodeficiency virus type 1 and Moloney murine leukemia virus enzymes prefer to cleave the RNA strand one nucleotide away from the RNA-DNA junction. 2. RNA 5'-end directed cleavage 13-19 nucleotides from the RNA end. 3. DNA 3'-end directed cleavage 15-20 nucleotides away from the primer terminus. 3'-end directed exonucleolytic cleavage of viral RNA-DNA hybrid. Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). |