PDB ID: 1ZSF
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|Header :||HYDROLASE/HYDROLASE INHIBITOR|
|Title :||Crystal Structure of Complex of a Hydroxyethylamine Inhibitor with HIV-1 Protease at 2.0A Resolution|
|Release Data :||2006-04-25|
|Authors :||Duskova, J., Skalova, T., Dohnalek, J., Petrokova, H., Hasek, J.|
|Keywords :||HIV, PROTEASE, PEPTIDOMIMETIC INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX|
|Exp. method :||X-RAY DIFFRACTION ( 1.98 Å )|
|Chain :||A, B|
|UniProt :||P03367 (POL_HV1BR)|
|Reaction :||Specific for a P1 residue that is hydrophobic, and P1' variable, but often Pro.
Endohydrolysis of RNA in RNA/DNA hybrids. Three different cleavage modes: 1. sequence-specific internal cleavage of RNA. Human immunodeficiency virus type 1 and Moloney murine leukemia virus enzymes prefer to cleave the RNA strand one nucleotide away from the RNA-DNA junction. 2. RNA 5'-end directed cleavage 13-19 nucleotides from the RNA end. 3. DNA 3'-end directed cleavage 15-20 nucleotides away from the primer terminus.
3'-end directed exonucleolytic cleavage of viral RNA-DNA hybrid.
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).