Brand  (β version)

PDB ID: 1ZRB

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Ligands
Code Name Style Show Link
062 3-aza-9-hydroxy-9-fluorenylcarbonyl-L-prolyl-2-aminomethyl-5-chlorobenzylamide, N-oxide PoSSuM
Non-standard Residues
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TYS O-sulfo-L-tyrosine
Glycosylation
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Structure summary

Code : 1ZRB   PDBj   RCSB PDB   PDBe
Header : BLOOD CLOTTING,HYDROLASE/INHIBITOR
Title : Thrombin in complex with an azafluorenyl inhibitor 23b
Release Data : 2005-06-07
Compound :
mol_id molecule chains synonym
1 thrombin A Coagulation factor II
ec: 3.4.21.5
fragment: alpha-thrombin
mol_id molecule chains
2 11-peptide hirudin fragment B
Source :
mol_id organism_scientific organism_common
1 Homo sapiens  (taxid:9606) Human
organ: PANCREAS
mol_id organism_scientific
2 Hirudo medicinalis  (taxid:6421)
synthetic: yes
Authors : Stauffer, K.J., Williams, P.D., Selnick, H.G., Nantermet, P.G., Newton, C.L., Homnick, C.F., Zrada, M.M., Lewis, S.D., Lucas, B.J., Krueger, J.A., Pietrak, B.L., Lyle, E.A., Singh, R., Miller-Stein, C., White, R.B., Wong, B., Wallace, A.A., Sitko, G.R., Cook, J.J., Holahan, M.A., Stranieri-Michener, M., Leonard, Y.M., Lynch Jr., J.J., McMasters, D.R., Yan, Y.
Keywords : thrombin; thrombin inhibitor complex, BLOOD CLOTTING, HYDROLASE-INHIBITOR COMPLEX
Exp. method : X-RAY DIFFRACTION ( 1.90 Å )
Citation :

9-hydroxyazafluorenes and their use in thrombin inhibitors

Stauffer, K.J.,Williams, P.D.,Selnick, H.G.  et al.
(2005)  J.Med.Chem.  48 : 2282 - 2293

PubMed: 15801822
DOI: 10.1021/jm049423s

Reaction

Chain : A
UniProt : P00734 (THRB_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B. 3.4.21.5 -
-
Chain : B
UniProt : P28504 (HIR2_HIRME)
Reaction : -