Brand  (β version)

PDB ID: 1ZQE

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Ligands
Code Name Style Show Link
CR Chromium ion PoSSuM
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Structure summary

Code : 1ZQE   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/DNA
Title : DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SEVEN BASE PAIRS OF DNA; SOAKED IN THE PRESENCE OF CRCL3 (SATURATED SOLUTION)
Release Data : 1996-04-12
Compound :
mol_id molecule chains
1 DNA (5'-D(*CP*AP*TP*TP*AP*GP*AP*A)-3') T
mol_id molecule chains
2 DNA (5'-D(*TP*CP*TP*AP*AP*TP*G)-3') P
mol_id molecule chains
3 PROTEIN (DNA POLYMERASE BETA (E.C.2.7.7.7)) A
Source :
mol_id organism_scientific
1
synthetic: yes
mol_id organism_scientific
2
synthetic: yes
mol_id organism_scientific organism_common expression_system
3 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
Authors : Pelletier, H., Sawaya, M.R.
Keywords : DNA-DIRECTED DNA POLYMERASE, DNA REPLICATION, DNA REPAIR, NUCLEOTIDYLTRANSFERASE, COMPLEX (NUCLEOTIDYLTRANSFERASE-DNA, TRANSFERASE-DNA complex
Exp. method : X-RAY DIFFRACTION ( 3.700 Å )
Citation :

Characterization of the metal ion binding helix-hairpin-helix motifs in human DNA polymerase beta by X-ray structural analysis.

Pelletier, H.,Sawaya, M.R.
(1996)  Biochemistry  35 : 12778 - 12787

PubMed: 8841120
DOI: 10.1021/bi960790i

Crystal Structures of Human DNA Polymerase Beta Complexed with Nicked and Gapped DNA Substrates

Sawaya, M.R.,Rawson, T.,Wilson, S.H.  et al.
To be Published 

The Role of Thumb Movement and Template Bending in Polymerase Fidelity

Pelletier, H.
To be Published 

Crystal Structures of Human DNA Polymerase Beta Complexed with DNA; Implications for Catalytic Mechanism, Processivity, and Fidelity

Pelletier, H.,Sawaya, M.R.,Wolfle, W.  et al.
(1996)  Biochemistry  35 : 12742

A Structural Basis for Metal Ion Mutagenicity and Nucleotide Selectivity in Human DNA Polymerase Beta

Pelletier, H.,Sawaya, M.R.,Wolfle, W.  et al.
(1996)  Biochemistry  35 : 12762

Polymerase Structures and Mechanism

Pelletier, H.
(1994)  Science  266 : 2025

Structures of Ternary Complexes of Rat DNA Polymerase Beta, a DNA Template- Primer, and ddCTP

Pelletier, H.,Sawaya, M.R.,Kumar, A.  et al.
(1994)  Science  264 : 1891

Crystal Structure of Rat DNA Polymerase Beta: Evidence for a Common Polymerase Mechanism

Sawaya, M.R.,Pelletier, H.,Kumar, A.  et al.
(1994)  Science  264 : 1930

Reaction

Chain : A
UniProt : P06746 (DPOLB_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1) 2.7.7.7 -
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a 5'-end 2'-deoxyribose-2'-deoxyribonucleotide-DNA = (2E,4S)- 4-hydroxypenten-2-al-5-phosphate + a 5'-end 5'-monophospho-2'- deoxyribonucleoside-DNA + H(+) - PubMed:9572863, PubMed:9614142
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2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'- deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3- dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho- 2'-deoxyribonucleoside-DNA + H(+) 4.2.99.18 PubMed:9614142
-