PDB ID: 1ZPK
Hetero Atom Contents
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hetatm:
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centroid:
interaction residue:
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Code | Name | Link |
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CL | Chloride ion | PoSSuM |
NA | Sodium ion | PoSSuM |
0ZS | N-{(2r,3s)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-4-phenylbutyl}-L-phenylalanyl-L-alpha-glutamyl-L-phenylalaninamide | PoSSuM |
Code | Name | Link |
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CME | S,S-(2-hydroxyethyl)thiocysteine | PoSSuM |
Download interaction data: 1ZPK
Structure summary
Code : | 1ZPK | ||||||||||||
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Header : | HYDROLASE/HYDROLASE INHIBITOR | ||||||||||||
Title : | Crystal structure of the complex of mutant HIV-1 protease (A71V, V82T, I84V) with a hydroxyethylamine peptidomimetic inhibitor BOC-PHE-PSI[R-CH(OH)CH2NH]-PHE-GLU-PHE-NH2 | ||||||||||||
Release Data : | 2006-04-25 | ||||||||||||
Compound : |
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Source : |
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Authors : | Duskova, J., Skalova, T., Dohnalek, J., Petrokova, H., Hasek, J. | ||||||||||||
Keywords : | HIV, PROTEASE, PEPTIDOMIMETIC INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 1.65 Å ) | ||||||||||||
Citation : |
Mutational Study of Pseudopeptide Inhibitor Binding to HIV-1 Protease; Analysis of Four X-ray Structures
Duskova, J.,Skalova, T.,Dohnalek, J.
et al.
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Reaction
Chain : | A, B |
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UniProt : | P03367 (POL_HV1BR) |
Reaction : | Specific for a P1 residue that is hydrophobic, and P1' variable, but often Pro. Endohydrolysis of RNA in RNA/DNA hybrids. Three different cleavage modes: 1. sequence-specific internal cleavage of RNA. Human immunodeficiency virus type 1 and Moloney murine leukemia virus enzymes prefer to cleave the RNA strand one nucleotide away from the RNA-DNA junction. 2. RNA 5'-end directed cleavage 13-19 nucleotides from the RNA end. 3. DNA 3'-end directed cleavage 15-20 nucleotides away from the primer terminus. 3'-end directed exonucleolytic cleavage of viral RNA-DNA hybrid. Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). |