Brand  (β version)

PDB ID: 1ZN7

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Ligands
Code Name Style Show Link
ADE Adenine PoSSuM
MG Magnesium ion PoSSuM
PO4 Phosphate ion PoSSuM
HSX 5-O-phosphono-alpha-D-ribofuranose PoSSuM
PRP 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose PoSSuM
Non-standard Residues
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Glycosylation
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Modification
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Structure summary

Code : 1ZN7   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Human Adenine Phosphoribosyltransferase Complexed with PRPP, ADE and R5P
Release Data : 2006-04-25
Compound :
mol_id molecule chains synonym
1 Adenine phosphoribosyltransferase A,B APRT
ec: 2.4.2.7
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
gene: APRT
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: pET29a
Authors : Iulek, J., Silva, M., Tomich, C.H.T.P., Thiemann, O.H.
Keywords : Transferase, Glycosyltransferase, Purine salvage
Exp. method : X-RAY DIFFRACTION ( 1.83 Å )
Citation :

Structural Complexes of Human Adenine Phosphoribosyltransferase Reveal Novel Features of the APRT Catalytic Mechanism

Silva, C.H.,Silva, M.,Iulek, J.  et al.
(2008)  J.Biomol.Struct.Dyn.  25 : 589 - 598

PubMed: 18399692

Reaction

Chain : A, B
UniProt : P07741 (APT_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine 2.4.2.7 PubMed:15196008
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