Brand  (β version)

PDB ID: 1ZLT

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Ligands
Code Name Style Show Link
HYM (4z)-4-(2-amino-5-oxo-3,5-dihydro-4h-imidazol-4-ylidene)-2,3-dichloro-4,5,6,7-tetrahydropyrrolo[2,3-C]azepin-8(1h)-one PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
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Structure summary

Code : 1ZLT   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal Structure of Chk1 Complexed with a Hymenaldisine Analog
Release Data : 2006-06-27
Compound :
mol_id molecule chains
1 Serine/threonine-protein kinase Chk1 A
ec: 2.7.1.37
fragment: Chk1Kd (Residues 1-289)
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: CHEK1, CHK1
expression_system_common: Fall armyworm
expression_system_strain: SF21
expression_system_vector_type: baculovirus
expression_system_plasmid: pFastBac1
Authors : Lee, C.C., Ng, K., Wan, Y., Gray, N., Spraggon, G.
Keywords : kinase, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 1.74 Å )
Citation :

Crystal Structure of Chk1 Complexed with a Hymenaldisine Analog

Lee, C.C.,Ng, K.,Wan, Y.  et al.
To be Published 

Reaction

Chain : A
UniProt : O14757 (CHK1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.1 PubMed:10673501, PubMed:12660173, PubMed:14559997, PubMed:15659650, PubMed:15665856, PubMed:16511572, PubMed:16963448, PubMed:17296736, PubMed:17380128, PubMed:18317453, PubMed:18728393, PubMed:31316063, PubMed:9278511
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ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.1 PubMed:10673501, PubMed:12660173, PubMed:14559997, PubMed:15659650, PubMed:15665856, PubMed:16511572, PubMed:16963448, PubMed:17296736, PubMed:17380128, PubMed:18317453, PubMed:18728393, PubMed:31316063, PubMed:9278511
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