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Ligands
Code Name Style Show Link
HG Mercury (II) ion
CL Chloride ion
MN Manganese (II) ion
UDP Uridine-5'-diphosphate
DR4 Methyl 9-(beta-D-talopyranosyloxy)nonanoate
Non-standard Residues
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Glycosylation
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Code : 1ZJP   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal Structure of Human Galactosyltransferase (GTB) Complexed with Galactose-grease
Release Data : 2005-12-13
Compound :
mol_id molecule chains
1 ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) A
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
expression_system_strain: BL21Gold
expression_system_vector_type: plasmid
expression_system_plasmid: PCW DELTA 1AC (E-H)
Authors : Letts, J.A., Rose, N.L., Fang, Y.R., Barry, C.H., Borisova, S.N., Seto, N.O., Palcic, M.M., Evans, S.V.
Keywords : GTB, ABO(H), blood group, H-antigen, glycosyltransferase, retaining, Transferase
Exp. method : X-RAY DIFFRACTION ( 1.59 Å )
Citation :

Differential Recognition of the Type I and II H Antigen Acceptors by the Human ABO(H) Blood Group A and B Glycosyltransferases.

Letts, J.A.,Rose, N.L.,Fang, Y.R.  et al.
(2006)  J.Biol.Chem.  281 : 3625 - 3632

PubMed: 16326711
DOI: 10.1074/jbc.M507620200

Chain : A
UniProt : P16442 (BGAT_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + UDP- N-acetyl-alpha-D-galactosamine = an N-acetyl-alpha-D-galactosaminyl- (1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H(+) + UDP 2.4.1.40 PubMed:12198488, PubMed:17259183
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an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + UDP- alpha-D-galactose = an alpha-D-galactosyl-(1->3)-[alpha-L-fucosyl- (1->2)]-beta-D-galactosyl derivative + H(+) + UDP 2.4.1.37 PubMed:12198488, PubMed:17259183
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