Brand  (β version)

PDB ID: 1ZJN

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Ligands
Code Name Style Show Link
DGT 2'-deoxyguanosine-5'-triphosphate PoSSuM
MG Magnesium ion PoSSuM
NA Sodium ion PoSSuM
Non-standard Residues
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Glycosylation
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Modification
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Structure summary

Code : 1ZJN   PDBj   RCSB PDB   PDBe
Header : DNA/LYASE/TRANSFERASE
Title : Human DNA Polymerase beta complexed with DNA containing an A-A mismatched primer terminus with dGTP
Release Data : 2005-08-16
Compound :
mol_id molecule chains
1 d(*CP*CP*GP*AP*CP*CP*AP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3' T
mol_id molecule chains
2 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*A)-3' P
mol_id molecule chains
3 5'-D(P*GP*TP*CP*GP*G)-3' D
mol_id molecule chains
4 DNA polymerase beta A
ec: 2.7.7.7, 4.2.99.-
Source :
mol_id organism_scientific
1
synthetic: yes
mol_id organism_scientific
2
synthetic: yes
mol_id organism_scientific
3
synthetic: yes
mol_id organism_scientific organism_common expression_system
4 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: POLB
Authors : Batra, V.K., Beard, W.A., Shock, D.D., Pedersen, L.C., Wilson, S.H.
Keywords : DNA/LYASE/TRANSFERASE, DNA-LYASE-TRANSFERASE complex
Exp. method : X-RAY DIFFRACTION ( 2.61 Å )
Citation :

Nucleotide-induced DNA polymerase active site motions accommodating a mutagenic DNA intermediate.

Batra, V.K.,Beard, W.A.,Shock, D.D.  et al.
(2005)  STRUCTURE  13 : 1225 - 1233

PubMed: 16084394
DOI: 10.1016/j.str.2005.05.010

Reaction

Chain : A
UniProt : P06746 (DPOLB_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1) 2.7.7.7 -
-
a 5'-end 2'-deoxyribose-2'-deoxyribonucleotide-DNA = (2E,4S)- 4-hydroxypenten-2-al-5-phosphate + a 5'-end 5'-monophospho-2'- deoxyribonucleoside-DNA + H(+) - PubMed:9572863, PubMed:9614142
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2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'- deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3- dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho- 2'-deoxyribonucleoside-DNA + H(+) 4.2.99.18 PubMed:9614142
-