Het-PDB Navi2 (PDB: 1ZET)

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Ligands
Code	Name		Style	Show	Link
MG	Magnesium ion				PoSSuM
TTP	Thymidine-5'-triphosphate				PoSSuM

Non-standard Residues
Code	Name	Show
BRU	5-bromo-2'-deoxyuridine-5'-monophosphate
DOC	2',3'-dideoxycytidine-5'-monophosphate

Glycosylation
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Modification
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Download interaction data: 1ZET

Code :

1ZET PDBj RCSB PDB PDBe

Header :

REPLICATION/DNA

Title :

X-ray data do not support hoogsteen base-pairing during replication by human polymerase iota

Release Data :

2005-07-19

Compound :

mol_id	molecule	chains
1	5'-D(PAPGPGPGP(BRU)PCPCP(BRU)P(BRU)PCPCPCPCPC)-3'	T

mol_id	molecule	chains
2	5'-D(GPGPGPGPGPAPAPGPGPAPCPCP*(DOC))-3'	P

mol_id	molecule	chains
3	Polymerase (DNA directed) iota	A

Source :

mol_id	organism_scientific
1
	synthetic: yes

mol_id	organism_scientific
2
	synthetic: yes

mol_id	organism_scientific	organism_common	expression_system
3	Homo sapiens (taxid:9606)	Human	Saccharomyces cerevisiae (taxid:4932)
	gene: POLI expression_system_common: Baker's yeast

Authors :

Wang, J.

Keywords :

PROTEIN, DNA, DTTP, STATISTICAL DYAD, REPLICATION-DNA COMPLEX

Exp. method :

X-RAY DIFFRACTION ( 2.30 Å )

Citation :

DNA polymerases: Hoogsteen base-pairing in DNA replication?

Wang, J.
(2005) Nature 437 : E6 - 7; discussion E7

Replication by human DNA polymerase-iota occurs by Hoogsteen base-pairing.

Nair, D.T.,Johnson, R.E.,Prakash, S. et al.
(2004) Nature 430 : 377 - 380

PDB ID: 1ZET