Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

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Ligands
Code Name Link
CL Chloride ion
ZN Zinc ion
CRS M-cresol
Code : 1ZEI
Header : HORMONE
Title : CROSS-LINKED B28 ASP INSULIN
Release Data : 1999-02-16
Compound :
mol_id molecule chains synonym
1 INSULIN A,B,C,D,E,F B28ASP-X-MCR
mutation: P28D
Source :
mol_id organism_scientific organism_common expression_system
1 Sus scrofa  (taxid:9823) Pig Saccharomyces cerevisiae  (taxid:4932)
expression_system_common: Baker's yeast
Authors : Whittingham, J.L., Edwards, E.J., Antson, A.A., Clarkson, J.M., Dodson, G.G.
Keywords : HORMONE, METABOLIC ROLE, CHEMICAL ACTIVITY, INSULIN MUTANT, CROSS-LINK, GLUCOSE METABOLISM, DIABETES
Exp. method : X-RAY DIFFRACTION ( 1.9 Å )
Citation :

Interactions of phenol and m-cresol in the insulin hexamer, and their effect on the association properties of B28 pro --> Asp insulin analogues.

Whittingham, J.L.,Edwards, D.J.,Antson, A.A.  et al.
(1998)  Biochemistry  37 : 11516 - 11523

PubMed: 9708987
DOI: 10.1021/bi980807s

Role of C-Terminal B-Chain Residues in Insulin Assembly: The Structure of Hexameric Lysb28Prob29-Human Insulin

Ciszak, E.,Beals, J.M.,Frank, B.H.  et al.
(1995)  Structure  3 : 615

The Structure of a Rhombohedral R6 Insulin Hexamer that Binds Phenol

Smith, G.D.,Dodson, G.G.
(1992)  Biopolymers  32 : 441

Chain : A, B, C, D, E, F
UniProt : P01315 (INS_PIG)
Reaction : -