Het-PDB Navi2 (PDB: 1Z2B)

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Ligands
Code	Name	Link
CN2	2-mercapto-N-[1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl]acetamide	PoSSuM
GDP	Guanosine-5'-diphosphate	PoSSuM
GTP	Guanosine-5'-triphosphate	PoSSuM
MG	Magnesium ion	PoSSuM
VLB	(2alpha,2'beta,3beta,4alpha,5beta)-vincaleukoblastine	PoSSuM

Non-standard Residues
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Download interaction data: 1Z2B

Code :

1Z2B PDBj RCSB PDB PDBe

Header :

CELL CYCLE

Title :

Tubulin-colchicine-vinblastine: stathmin-like domain complex

Release Data :

2005-05-31

Compound :

mol_id	molecule	chains
1	Tubulin alpha chain	A,C

mol_id	molecule	chains
2	Tubulin beta chain	B,D

mol_id	molecule	chains	synonym
3	RB3 STATHMIN-LIKE DOMAIN 4	E	Stathmin-like protein B3, RB3-SLD

Source :

mol_id	organism_scientific	organism_common
1	Bos taurus (taxid:9913)	Cattle
	organ: BRAIN other_details: BRAIN

mol_id	organism_scientific	organism_common
2	Bos taurus (taxid:9913)	Cattle
	organ: BRAIN other_details: BRAIN

mol_id	organism_scientific	organism_common	expression_system
3	Rattus norvegicus (taxid:10116)	Norway rat	Escherichia coli BL21(DE3) (taxid:469008)
	gene: Stmn4 expression_system_strain: BL21(DE3) expression_system_vector_type: PLASMID expression_system_plasmid: PET-8C

Authors :

Gigant, B., Wang, C., Ravelli, R.B.G., Roussi, F., Steinmetz, M.O., Curmi, P.A., Sobel, A., Knossow, M.

Keywords :

ALPHA-TUBULIN, BETA-TUBULIN, COLCHICINE, GTPASE, MICROTUBULE, STATHMIN, TUBULIN, VINBLASTINE, CELL CYCLE

Exp. method :

X-RAY DIFFRACTION ( 4.10 Å )

Citation :

Structural basis for the regulation of tubulin by vinblastine.

Gigant, B.,Wang, C.,Ravelli, R.B. et al.
(2005) Nature 435 : 519 - 522

PDB ID: 1Z2B