Brand  (β version)

PDB ID: 1Z10

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Ligands
Code Name Style Show Link
HEM Protoporphyrin ix containing Fe PoSSuM
COU Coumarin PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1Z10   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Crystal Structure of Human Microsomal P450 2A6 with Coumarin Bound
Release Data : 2005-08-16
Compound :
mol_id molecule chains
1 cytochrome P450, family 2, subfamily A, polypeptide 6 A,B,C,D
ec: 1.14.14.1
fragment: catalytic domain
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: CYP2A6
expression_system_strain: DH-5 alpha
expression_system_vector_type: plasmid
expression_system_plasmid: pCWori
Authors : Yano, J.K., Hsu, M.H., Griffin, K.J., Stout, C.D., Johnson, E.F.
Keywords : CYP2A6, P450 2A6, P450, monooxygenase, drug metabolizing enzyme, coumarin 7-hydroxylase, nicotine oxidase, oxidoreductase, heme
Exp. method : X-RAY DIFFRACTION ( 1.90 Å )
Citation :

Structures of human microsomal cytochrome P450 2A6 complexed with coumarin and methoxsalen

Yano, J.K.,Hsu, M.H.,Griffin, K.J.  et al.
(2005)  Nat.Struct.Mol.Biol.  12 : 822 - 823

PubMed: 16086027
DOI: 10.1038/nsmb971

Reaction

Chain : A, B, C, D
UniProt : P11509 (CP2A6_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
1,4-cineole + O2 + reduced [NADPH--hemoprotein reductase] = 2- exo-hydroxy-1,4-cineole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] - PubMed:11695850
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