Brand  (β version)

PDB ID: 1YQ7

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Ligands
Code Name Style Show Link
MG Magnesium ion PoSSuM
PO4 Phosphate ion PoSSuM
RIS 1-hydroxy-2-(3-pyridinyl)ethylidene bis-phosphonic acid PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1YQ7   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Human farnesyl diphosphate synthase complexed with risedronate
Release Data : 2005-02-22
Compound :
mol_id molecule chains synonym
1 Farnesyl pyrophosphate synthetase A farnesyl diphosphate, FPP synthetase, FPS, Farnesyl diphosphate synthetase, Geranyltranstransferase
ec: 2.5.1.10
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
gene: FDPS
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: pET11 derivative
Authors : Kavanagh, K.L., Guo, K., Von delft, F., Arrowsmith, C., Sundstrom, M., Edwards, A., Oppermann, U., Structural Genomics Consortium (SGC)
Keywords : isoprenoid pathway, cholesterol biosynthesis, bisphosphonate inhibitor, Structural Genomics, Structural Genomics Consortium, SGC, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.20 Å )
Citation :

Human farnesyl diphosphate complexed with clinical inhibitor risedronate

Kavanagh, K.L.,Guo, K.,Oppermann, U.
To be Published 

Reaction

Chain : A
UniProt : P14324 (FPPS_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
dimethylallyl diphosphate + isopentenyl diphosphate = (2E)- geranyl diphosphate + diphosphate 2.5.1.1 PubMed:16684881
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(2E)-geranyl diphosphate + isopentenyl diphosphate = (2E,6E)- farnesyl diphosphate + diphosphate 2.5.1.10 PubMed:16684881
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