Brand  (β version)

PDB ID: 1YLZ

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Ligands
Code Name Style Show Link
PO4 Phosphate ion PoSSuM
CB4 Pinacol[[2-amino-alpha-(1-carboxy-1-methylethoxyimino)-4-thiazoleacetyl]amino]methaneboronate PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1YLZ   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : X-ray crystallographic structure of CTX-M-14 beta-lactamase complexed with ceftazidime-like boronic acid
Release Data : 2005-04-26
Compound :
mol_id molecule chains
1 BETA-LACTAMASE CTX-M-14 A,B
ec: 3.5.2.6
Source :
mol_id organism_scientific expression_system
1 Escherichia coli  (taxid:562) Escherichia coli BL21(DE3)  (taxid:469008)
gene: CTX-M
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: pET-9a
Authors : Chen, Y., Shoichet, B., Bonnet, R.
Keywords : CTX-M, beta-lactamase, transition state, ceftazidime, boronic acid, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 1.35 Å )
Citation :

Structure, Function, and Inhibition along the Reaction Coordinate of CTX-M beta-Lactamases.

Chen, Y.,Shoichet, B.,Bonnet, R.
(2005)  J.Am.Chem.Soc.  127 : 5423 - 5434

PubMed: 15826180
DOI: 10.1021/ja042850a

Reaction

Chain : A, B
UniProt : Q9L5C7 (Q9L5C7_ECOLX)
Reaction: EC: Evidence:
Physiological Direction:
a beta-lactam + H2O = a substituted beta-amino acid 3.5.2.6 ARBA:ARBA00001526, RuleBase:RU361140
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