Brand  (β version)

PDB ID: 1YHY

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Ligands
Code Name Style Show Link
MG Magnesium ion PoSSuM
1MM Methyl 2-[({[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate PoSSuM
NHE 2-[N-cyclohexylamino]ethane sulfonic acid PoSSuM
FAD Flavin-adenine dinucleotide PoSSuM
P22 Ethyl dihydrogen diphosphate PoSSuM
Non-standard Residues
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CSD 3-sulfinoalanine
Glycosylation
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Modification
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Structure summary

Code : 1YHY   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal structure of Arabidopsis thaliana Acetohydroxyacid synthase In Complex With A Sulfonylurea Herbicide, Metsulfuron methyl
Release Data : 2006-01-17
Compound :
mol_id molecule chains synonym
1 Acetolactate synthase A Acetohydroxy-acid synthase, ALS
ec: 2.2.1.6
fragment: residues 86-667
Source :
mol_id organism_scientific organism_common expression_system
1 Arabidopsis thaliana  (taxid:3702) Thale cress Escherichia coli BL21(DE3)  (taxid:469008)
gene: ILVB
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: pET30a(+)
Authors : McCourt, J.A., Pang, S.S., King-Scott, J., Guddat, L.W., Duggleby, R.G.
Keywords : Acetohydroxyacid synthase, acetolactate synthase, herbicide, sulfonylurea, thiamin diphosphate, FAD, inhibitor, cysteine-s-dioxide, CHES, metsulfuron methyl, Transferase
Exp. method : X-RAY DIFFRACTION ( 2.70 Å )
Citation :

Herbicide-binding sites revealed in the structure of plant acetohydroxyacid synthase

McCourt, J.A.,Pang, S.S.,King-Scott, J.  et al.
(2006)  Proc.Natl.Acad.Sci.Usa  103 : 569 - 573

PubMed: 16407096
DOI: 10.1073/pnas.0508701103

Reaction

Chain : A
UniProt : P17597 (ILVB_ARATH)
Reaction: EC: Evidence:
Physiological Direction:
H(+) + 2 pyruvate = (2S)-2-acetolactate + CO2 2.2.1.6 -
-