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Ligands
Code Name Style Show Link
CA Calcium ion
SO4 Sulfate ion
905 (R)-4-[2-(3-amino-benzenesulfonylamino)-1-(3,5-diethoxy-2-fluorophenyl)-2-oxo-ethylamino]-2-hydroxy-benzamidine
Non-standard Residues
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Code : 1YGC   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Short Factor VIIa with a small molecule inhibitor
Release Data : 2005-01-18
Compound :
mol_id molecule chains synonym
1 Coagulation factor VII H Serum prothrombin conversion accelerator, SPCA, Proconvertin, Eptacog alfa
ec: 3.4.21.21
fragment: heavy chain (residues 213-466)
mol_id molecule chains synonym
2 Coagulation factor VII L Serum prothrombin conversion accelerator, SPCA, Proconvertin, Eptacog alfa
fragment: light chain, del 1-149 from full length (residues 150-212)
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: F7
expression_system_common: Fall armyworm
expression_system_strain: High Five
expression_system_vector_type: virus
expression_system_plasmid: gp67ssFVII
mol_id organism_scientific organism_common expression_system
2 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: F7
expression_system_common: Fall armyworm
expression_system_strain: High Five
expression_system_vector_type: virus
expression_system_plasmid: gp67ssFVII
Authors : Olivero, A.G., Eigenbrot, C., Goldsmith, R., Robarge, K., Artis, D.R., Flygare, J., Rawson, T., Refino, C., Bunting, S., Kirchhofer, D.
Keywords : inverted oxy-anion hole, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 2.00 Å )
Citation :

A selective, slow binding inhibitor of factor VIIa binds to a nonstandard active site conformation and attenuates thrombus formation in vivo.

Olivero, A.G.,Eigenbrot, C.,Goldsmith, R.  et al.
(2005)  J.Biol.Chem.  280 : 9160 - 9169

PubMed: 15632123
DOI: 10.1074/jbc.M409068200

Chain : L
UniProt : P08709 (FA7_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Selective cleavage of Arg-|-Ile bond in factor X to form factor Xa. 3.4.21.21 -
-