Brand  (β version)

PDB ID: 1Y91

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Ligands
Code Name Style Show Link
CT9 4-[5-(trans-4-aminocyclohexylamino)-3-isopropylpyrazolo[1,5-a]pyrimidin-7-ylamino]-N,N-dimethylbenzenesulfonamide PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1Y91   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal structure of human CDK2 complexed with a pyrazolo[1,5-a]pyrimidine inhibitor
Release Data : 2005-02-08
Compound :
mol_id molecule chains synonym
1 Cell division protein kinase 2 A p33 protein kinase
ec: 2.7.1.37
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: CDK2
expression_system_common: Fall armyworm
expression_system_strain: SF21
expression_system_vector_type: Baculovirus
Authors : Williamson, D.S., Parratt, M.J., Torrance, C.J., Bower, J.F., Moore, J.D., Richardson, C.M., Dokurno, P., Cansfield, A.D., Francis, G.L., Hebdon, R.J., Howes, R., Jackson, P.S., Lockie, A.M., Murray, J.B., Nunns, C.L., Powles, J., Robertson, A., Surgenor, A.E.
Keywords : Serine/Threonine protein kinase, CDK2, ATP-binding, Cell cycle, mitosis, phosphorylation, pyrazolopyrimidine inhibitor, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.15 Å )
Citation :

Structure-guided design of pyrazolo[1,5-a]pyrimidines as inhibitors of human cyclin-dependent kinase 2.

Williamson, D.S.,Parratt, M.J.,Bower, J.F.  et al.
(2005)  Bioorg.Med.Chem.Lett.  15 : 863 - 867

PubMed: 15686876
DOI: 10.1016/j.bmcl.2004.12.073

Reaction

Chain : A
UniProt : P24941 (CDK2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.22 PubMed:1396589, PubMed:28666995, PubMed:9030781
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ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.22 PubMed:1396589, PubMed:28666995, PubMed:9030781
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