Brand  (β version)

PDB ID: 1Y5R

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Ligands
Code Name Style Show Link
NDP Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate PoSSuM
C0R Corticosterone PoSSuM
Non-standard Residues
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Glycosylation
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Modification
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Structure summary

Code : 1Y5R   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : The crystal structure of murine 11b-hydroxysteroid dehydrogenase complexed with corticosterone
Release Data : 2005-05-17
Compound :
mol_id molecule chains synonym
1 Corticosteroid 11-beta-dehydrogenase, isozyme 1 A,B 11-DH, 11-beta-hydroxysteroid dehydrogenase 1, 11-beta-HSD1, 11beta- HSD1A
ec: 1.1.1.146
Source :
mol_id organism_scientific organism_common expression_system
1 Mus musculus  (taxid:10090) House mouse Escherichia coli  (taxid:562)
gene: Hsd11b1
expression_system_strain: GM221
expression_system_vector_type: plasmid
expression_system_plasmid: pAMG21
Authors : Zhang, J., Osslund, T.D., Plant, M.H., Clogston, C.L., Nybo, R.E., Xiong, F., Delaney, J.M., Jordan, S.
Keywords : corticosterone bound, OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 3.0 Å )
Citation :

Crystal Structure of Murine 11-Hydroxysteroid Dehydrogenase 1: An Important Therapeutic Target for Diabetes

Zhang, J.,Osslund, T.D.,Plant, M.H.  et al.
(2005)  Biochemistry  44 : 6948 - 6957

PubMed: 15865440
DOI: 10.1021/bi047599q

Reaction

Chain : A, B
UniProt : P50172 (DHI1_MOUSE)
Reaction: EC: Evidence:
Physiological Direction:
an 11beta-hydroxysteroid + NADP(+) = an 11-oxosteroid + H(+) + NADPH 1.1.1.146 PubMed:23415904, PubMed:30902677, PubMed:9405715
right-to-left PubMed:23415904, PubMed:30902677, PubMed:9405715
corticosterone + NADP(+) = 11-dehydrocorticosterone + H(+) + NADPH - PubMed:23415904, PubMed:30902677, PubMed:9405715
right-to-left
a 7beta-hydroxysteroid + NADP(+) = a 7-oxosteroid + H(+) + NADPH 1.1.1.201 PubMed:23415904
right-to-left
7-oxocholesterol + H(+) + NADPH = 7beta-hydroxycholesterol + NADP(+) - PubMed:23415904
left-to-right
chenodeoxycholate + NADP(+) = 7-oxolithocholate + H(+) + NADPH - UniProtKB:P28845
right-to-left
7-oxolithocholate + H(+) + NADPH = NADP(+) + ursodeoxycholate - UniProtKB:P28845
left-to-right
glycochenodeoxycholate + NADP(+) = 7-oxoglycolithocholate + H(+) + NADPH - UniProtKB:P28845
right-to-left
NADP(+) + taurochenodeoxycholate = 7-oxotaurolithocholate + H(+) + NADPH - UniProtKB:P28845
right-to-left
NADP(+) + tauroursodeoxycholate = 7-oxotaurolithocholate + H(+) + NADPH - UniProtKB:P28845
right-to-left
glycoursodeoxycholate + NADP(+) = 7-oxoglycolithocholate + H(+) + NADPH - UniProtKB:P28845
right-to-left
7-oxopregnenolone + H(+) + NADPH = 7beta-hydroxypregnenolone + NADP(+) - UniProtKB:P28845
left-to-right
3beta,7alpha-dihydroxyandrost-5-en-17-one + NADP(+) = 3beta- hydroxy-5-androstene-7,17-dione + H(+) + NADPH - UniProtKB:P28845
left-to-right
3beta-hydroxy-5-androstene-7,17-dione + H(+) + NADPH = 3beta,7beta-dihydroxyandrost-5-en-17-one + NADP(+) - UniProtKB:P28845
left-to-right
3beta-hydroxy-5alpha-androstane-7,17-dione + H(+) + NADPH = 3beta,7beta-dihydroxy-5alpha-androstan-17-one + NADP(+) - UniProtKB:P28845
left-to-right