Het-PDB Navi2 (PDB: 1XV9)

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Ligands
Code	Name		Style	Show	Link
F15	Pentadecanoic acid				PoSSuM

Non-standard Residues
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Download interaction data: 1XV9

Code :

1XV9 PDBj RCSB PDB PDBe

Header :

DNA BINDING PROTEIN

Title :

crystal structure of CAR/RXR heterodimer bound with SRC1 peptide, fatty acid, and 5b-pregnane-3,20-dione.

Release Data :

2004-12-28

Compound :

mol_id	molecule	chains	synonym
1	Retinoic acid receptor RXR-alpha	A,C	Retinoid X receptor alpha
	fragment: LBD domain

mol_id	molecule	chains	synonym
2	Orphan nuclear receptor NR1I3	B,D	Constitutive androstane receptor, CAR, Orphan nuclear receptor MB67
	fragment: LBD domain

mol_id	molecule	chains
3	nuclear receptor coactivator 1 isoform 1	E,F,G,H
	fragment: peptide fragment-13 residues

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: RXRA, NR2B1

mol_id	organism_scientific	organism_common	expression_system
2	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)

mol_id	organism_scientific
3	Homo sapiens (taxid:9606)
	synthetic: yes other_details: Chemically synthesized

Authors :

Xu, R.X., Lambert, M.H., Wisely, B.B., Warren, E.N., Weinert, E.E., Waitt, G.M., Williams, J.D., Moore, L.B., Willson, T.M., Moore, J.T.

Keywords :

CAR, RXR, SRC1, pregnanedione, DNA BINDING PROTEIN

Exp. method :

X-RAY DIFFRACTION ( 2.7 Å )

Citation :

A Structural Basis for Constitutive Activity in the Human CAR/RXRalpha Heterodimer.

Xu, R.X.,Lambert, M.H.,Wisely, B.B. et al.
(2004) Mol.Cell 16 : 919 - 928

PDB ID: 1XV9