Brand  (β version)

PDB ID: 1XS6

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Ligands
Code Name Style Show Link
MG Magnesium ion PoSSuM
DUT Deoxyuridine-5'-triphosphate PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1XS6   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : dCTP deaminase from Escherichia coli. E138A mutant enzyme in complex with dUTP
Release Data : 2004-12-21
Compound :
mol_id molecule chains synonym
1 Deoxycytidine triphosphate deaminase A,B,C,D,E,F dCTP deaminase
ec: 3.5.4.13
mutation: E138A
Source :
mol_id organism_scientific expression_system
1 Escherichia coli  (taxid:562) Escherichia coli BL21(DE3)  (taxid:469008)
gene: dcd
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: pET11a
Authors : Johansson, E., Fano, M., Bynck, J.H., Neuhard, J., Larsen, S., Sigurskjold, B.W., Christensen, U., Willemoes, M.
Keywords : dCTP deaminase, nucleotide metabolism, trimer, hydrolase
Exp. method : X-RAY DIFFRACTION ( 2.00 Å )
Citation :

Structures of dCTP deaminase from Escherichia coli with bound substrate and product: reaction mechanism and determinants of mono- and bifunctionality for a family of enzymes

Johansson, E.,Fano, M.,Bynck, J.H.  et al.
(2005)  J.Biol.Chem.  280 : 3051 - 3059

PubMed: 15539408
DOI: 10.1074/jbc.M409534200

Reaction

Chain : A, B, C, D, E, F
UniProt : P28248 (DCD_ECOLI)
Reaction: EC: Evidence:
Physiological Direction:
dCTP + H(+) + H2O = dUTP + NH4(+) 3.5.4.13 HAMAP-Rule:MF_00146, PubMed:1324907, PubMed:15539408, PubMed:17651436, PubMed:17996716
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