Het-PDB Navi2 (PDB: 1XR2)

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Ligands
Code	Name	Link
SO4	Sulfate ion	PoSSuM
C2F	5-methyl-5,6,7,8-tetrahydrofolic acid	PoSSuM
MRY	Meso-erythritol	PoSSuM

Non-standard Residues
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Download interaction data: 1XR2

Code :

1XR2 PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

Crystal Structure of oxidized T. maritima Cobalamin-Independent Methionine Synthase complexed with Methyltetrahydrofolate

Release Data :

2005-03-01

Compound :

mol_id	molecule	chains	synonym
1	5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase	A,B	Methionine synthase, vitamin-B12 independent isozyme, Cobalamin-independent methionine synthase
	ec: 2.1.1.14

Source :

mol_id	organism_scientific	expression_system
1	Thermotoga maritima (taxid:2336)	Escherichia coli (taxid:562)
	gene: metE expression_system_strain: BL21(DE3)STAR expression_system_vector_type: PLASMID expression_system_plasmid: PET151D-TOPO

Authors :

Pejchal, R., Ludwig, M.L.

Keywords :

TIM barrel, zinc, homocysteine, methyltetrahydrofolate, TRANSFERASE

Exp. method :

X-RAY DIFFRACTION ( 2.35 Å )

Citation :

Cobalamin-independent methionine synthase (MetE): a face-to-face double barrel that evolved by gene duplication

Pejchal, R.,Ludwig, M.L.
(2005) Plos Biol. 3 : e31

Chain :

A, B

UniProt :

Q9X112 (METE_THEMA)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine	2.1.1.14	HAMAP-Rule:MF_00172
	-	HAMAP-Rule:MF_00172
Cofactor:	Evidence:	Note:
Zn(2+)	ECO:0000255 \| HAMAP-Rule:MF_00172 ECO:0000269 \| PubMed:15630480 ECO:0000269 \| PubMed:18296644	Binds 1 zinc ion per subunit.

PDB ID: 1XR2