Brand  (β version)

PDB ID: 1XR2

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Ligands
Code Name Style Show Link
SO4 Sulfate ion PoSSuM
C2F 5-methyl-5,6,7,8-tetrahydrofolic acid PoSSuM
MRY Meso-erythritol PoSSuM
Non-standard Residues
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Structure summary

Code : 1XR2   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal Structure of oxidized T. maritima Cobalamin-Independent Methionine Synthase complexed with Methyltetrahydrofolate
Release Data : 2005-03-01
Compound :
mol_id molecule chains synonym
1 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase A,B Methionine synthase, vitamin-B12 independent isozyme, Cobalamin-independent methionine synthase
ec: 2.1.1.14
Source :
mol_id organism_scientific expression_system
1 Thermotoga maritima  (taxid:2336) Escherichia coli  (taxid:562)
gene: metE
expression_system_strain: BL21(DE3)STAR
expression_system_vector_type: PLASMID
expression_system_plasmid: PET151D-TOPO
Authors : Pejchal, R., Ludwig, M.L.
Keywords : TIM barrel, zinc, homocysteine, methyltetrahydrofolate, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.35 Å )
Citation :

Cobalamin-independent methionine synthase (MetE): a face-to-face double barrel that evolved by gene duplication

Pejchal, R.,Ludwig, M.L.
(2005)  Plos Biol.  3 : e31

PubMed: 15630480
DOI: 10.1371/journal.pbio.0030031

Reaction

Chain : A, B
UniProt : Q9X112 (METE_THEMA)
Reaction: EC: Evidence:
Physiological Direction:
5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = L- methionine + tetrahydropteroyltri-L-glutamate 2.1.1.14 HAMAP- Rule:MF_00172
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