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Ligands
Code Name Style Show Link
SAH S-adenosyl-L-homocysteine
Non-standard Residues
Code Name Show
MLZ N-methyl-lysine
Glycosylation
Code Name Emphasize
Modification
Code Name Show
Code : 1XQH   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal structure of a ternary complex of the methyltransferase SET9 (also known as SET7/9) with a P53 peptide and SAH
Release Data : 2004-11-23
Compound :
mol_id molecule chains synonym
1 Histone-lysine N-methyltransferase, H3 lysine-4 specific A,E LYSINE N-METHYLTRANSFERASE, Histone H3-K4 methyltransferase, H3-K4-HMTase, SET domain- containing Set7, Set9, SET7/9
ec: 2.1.1.43
fragment: N-domain, SET-domain
mol_id molecule chains
2 9-mer peptide from tumor protein p53 B,F
fragment: mono-methylated p53 peptide
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
expression_system_strain: BL21(DE3)
expression_system_vector_type: PLASMID
expression_system_plasmid: pGEX-6P
mol_id organism_scientific
2
synthetic: yes
other_details: This sequence occurs naturally in humans.
Authors : Chuikov, S., Kurash, J.K., Wilson, J.R., Xiao, B., Justin, N., Ivanov, G.S., McKinney, K., Tempst, P., Prives, C., Gamblin, S.J., Barlev, N.A., Reinberg, D.
Keywords : Set9-p53 complex, Set-domain, Lysine methylation, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 1.75 Å )
Citation :

Regulation of p53 activity through lysine methylation

Chuikov, S.,Kurash, J.K.,Wilson, J.R.  et al.
(2004)  Nature  432 : 353 - 360

PubMed: 15525938
DOI: 10.1038/nature03117

Chain : A, E
UniProt : Q8WTS6 (SETD7_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine 2.1.1.364 PROSITE-ProRule:PRU00910, PubMed:12540855
-
L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N(6)- methyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine - PubMed:15099517, PubMed:15525938, PubMed:16415881
left-to-right
Chain : B, F
UniProt : P04637 (P53_HUMAN)
Reaction : -