Het-PDB Navi2 (PDB: 1XO2)

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Ligands
Code	Name		Style	Show	Link
FSE	3,7,3',4'-tetrahydroxyflavone				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 1XO2

Code :

1XO2 PDBj RCSB PDB PDBe

Header :

CELL CYCLE/TRANSFERASE

Title :

Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin

Release Data :

2005-03-01

Compound :

mol_id	molecule	chains	synonym
1	Cyclin	A	V-cyclin

mol_id	molecule	chains	synonym
2	Cell division protein kinase 6	B	Serine/threonine-protein kinase PLSTIRE
	ec: 2.7.1.37

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Saimiriine herpesvirus 2 (taxid:10381)	Herpesvirus saimiri	Escherichia coli (taxid:562)
	gene: 72, ECLF2 expression_system_cell_line: sf-9 expression_system_vector_type: plasmid expression_system_plasmid: pFASTBacHTa

mol_id	organism_scientific	organism_common	expression_system
2	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: CDK6 expression_system_cell_line: sf-9 expression_system_vector_type: plasmid expression_system_plasmid: pFASTBac1

Authors :

Lu, H.S., Chang, D.J., Baratte, B., Meijer, L., Schulze-Gahmen, U.

Keywords :

human cyclin-dependent kinase 6, fisetin, CELL CYCLE-TRANSFERASE COMPLEX

Exp. method :

X-RAY DIFFRACTION ( 2.9 Å )

Citation :

Crystal Structure of a Human Cyclin-Dependent Kinase 6 Complex with a Flavonol Inhibitor, Fisetin.

Lu, H.S.,Chang, D.J.,Baratte, B. et al.
(2005) J.Med.Chem. 48 : 737 - 747

PDB ID: 1XO2