Brand  (β version)

PDB ID: 1XJG

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Ligands
Code Name Style Show Link
DTP 2'-deoxyadenosine 5'-triphosphate PoSSuM
MG Magnesium ion PoSSuM
UDP Uridine-5'-diphosphate PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1XJG   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Structural mechanism of allosteric substrate specificity in a ribonucleotide reductase: dATP-UDP complex
Release Data : 2005-12-20
Compound :
mol_id molecule chains
1 ribonucleotide reductase, B12-dependent A,B
ec: 1.17.4.1
fragment: residues 1-644
Source :
mol_id organism_scientific expression_system
1 Thermotoga maritima  (taxid:2336) Escherichia coli BL21(DE3)  (taxid:469008)
gene: nrdj
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: pET-22b
Authors : Larsson, K.-M., Jordan, A., Eliasson, R., Reichard, P., Logan, D.T., Nordlund, P.
Keywords : ribonucleotide reductase, 10 alpha-beta barrel, allosteric regulation, substrate specificity, protein-nucleotide complex, OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 2.50 Å )
Citation :

Structural Mechanism of Allosteric Substrate Specificity Regulation in a Ribonucleotide Reductase

Larsson, K.-M.,Jordan, A.,Eliasson, R.  et al.
(2004)  Nat.Struct.Mol.Biol.  11 : 1142 - 1149

PubMed: 15475969
DOI: 10.1038/nsmb838

Reaction

Chain : A, B
UniProt : O33839 (O33839_THEMT)
Reaction: EC: Evidence:
Physiological Direction:
[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'- diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'- diphosphate 1.17.4.1 ARBA:ARBA00000206, RuleBase:RU364064
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