Brand  (β version)

PDB ID: 1XI2

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Ligands
Code Name Style Show Link
CB1 5-(aziridin-1-yl)-2,4-dinitrobenzamide PoSSuM
FAD Flavin-adenine dinucleotide PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
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Structure summary

Code : 1XI2   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Quinone Reductase 2 in Complex with Cancer Prodrug CB1954
Release Data : 2005-08-30
Compound :
mol_id molecule chains synonym
1 NRH dehydrogenase [quinone] 2 A,B Quinone reductase 2, QR2, NRH:quinone oxidoreductase 2
ec: 1.6.99.-
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: NQO2, NMOR2
Authors : Fu, Y., Buryanovskyy, L., Zhang, Z.
Keywords : QR2, CB1954, OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 1.5 Å )
Citation :

Crystal structure of quinone reductase 2 in complex with cancer prodrug CB1954

Fu, Y.,Buryanovskyy, L.,Zhang, Z.
(2005)  Biochem.Biophys.Res.Commun.  336 : 332 - 338

PubMed: 16129418
DOI: 10.1016/j.bbrc.2005.08.081

Reaction

Chain : A, B
UniProt : P16083 (NQO2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone + H(+) = a quinol + beta-nicotinamide D-riboside 1.10.5.1 PubMed:18579530
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