Brand  (β version)

color scheme of protein:

hetatm:

chain: Hide other chain(s)

Code Name Link
DRA 11-deoxy-beta-rhodomycin
MSE Selenomethionine
SAM S-adenosylmethionine
Code : 1XDS
Header : transferase
Title : crystal structure of aclacinomycin-10-hydroxylase (rdmb) in complex with S-adenosyl-L-methionine (sam) and 11-deoxy- beta-rhodomycin (dbra)
Release Data : 2004-11-23
Compound :
mol_id 1
molecule protein rdmb
chain A, B
engineered yes
Source :
mol_id 1
organism_scientific Streptomyces purpurascens
organism_taxid 1924
gene rdmb
expression_system Escherichia coli
expression_system_taxid 562
expression_system_vector_type plasmid
expression_system_plasmid prdm16 from pgex4t-3
Authors : A.Jansson, H.Koskiniemi, A.Erola, J.Wang, P.Mantsala, G.Schneider, J.Niemi, Structural Proteomics In Europe (Spine)
Keywords : anthracycline; hydroxylase; s-adenosyl-l-methionine; streptomyces; polyketide antibiotics; divergent evolution, structural proteomics in europe, spine, structural genomics, transferase
Exp. method : X-ray diffraction ( 2.3 Å )
Chain : A, B
UniProt : Q54527 (RDMB_STREF)
Reaction : 15-demethoxyaclacinomycin + reduced acceptor + O(2) + H(+) = 10-decarboxymethylaclacinomycin + CO(2) + acceptor + H(2)O.