Brand  (β version)

PDB ID: 1XDK

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Ligands
Code Name Style Show Link
9CR (9cis)-retinoic acid PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1XDK   PDBj   RCSB PDB   PDBe
Header : HORMONE/GROWTH FACTOR RECEPTOR
Title : Crystal Structure of the RARbeta/RXRalpha Ligand Binding Domain Heterodimer in Complex with 9-cis Retinoic Acid and a Fragment of the TRAP220 Coactivator
Release Data : 2004-11-09
Compound :
mol_id molecule chains
1 Retinoic acid receptor RXR-alpha A,E
fragment: Ligand-Binding Domain
mol_id molecule chains synonym
2 Retinoic acid receptor, beta B,F RAR-beta
fragment: Ligand-Binding Domain
mol_id molecule chains synonym
3 Thyroid Receptor Associated Protein 220 C,D,G,H TRAP220
fragment: Nuclear Receptor Box 2
Source :
mol_id organism_scientific organism_common expression_system
1 Mus musculus  (taxid:10090) House mouse Escherichia coli BL21(DE3)  (taxid:469008)
gene: Rxra, Nr2b1
expression_system_strain: BL21(DE3)
expression_system_vector_type: pET3-a
mol_id organism_scientific organism_common expression_system
2 Mus musculus  (taxid:10090) House mouse Escherichia coli BL21(DE3)  (taxid:469008)
gene: Rarb, Nr1b2
expression_system_strain: BL21(DE3)
expression_system_vector_type: pET15-b
mol_id organism_scientific
3
synthetic: yes
other_details: The peptide was chemically synthesized. The sequence of the peptide is naturally found in Mus musculus (mouse).
Authors : Pogenberg, V., Guichou, J.F., Vivat-Hannah, V., Kammerer, S., Perez, E., Germain, P., De Lera, A.R., Gronemeyer, H., Royer, C.A., Bourguet, W.
Keywords : Nuclear Receptor, Coactivator, Ligand, HORMONE-GROWTH FACTOR RECEPTOR COMPLEX
Exp. method : X-RAY DIFFRACTION ( 2.90 Å )
Citation :

CHARACTERIZATION OF THE INTERACTION BETWEEN RAR/RXR HETERODIMERS AND TRANSCRIPTIONAL COACTIVATORS THROUGH STRUCTURAL AND FLUORESCENCE ANISOTROPY STUDIES

Pogenberg, V.,Guichou, J.F.,Vivat-Hannah, V.  et al.
(2005)  J.Biol.Chem.  280 : 1625 - 1633

PubMed: 15528208
DOI: 10.1074/jbc.M409302200

Reaction

Chain : A, E
UniProt : P28700 (RXRA_MOUSE)
Reaction : -
Chain : B, F
UniProt : P22605 (RARB_MOUSE)
Reaction : -
Chain : C, D, G, H
UniProt : Q8BX19
Reaction : -