Het-PDB Navi2 (PDB: 1XAI)

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Ligands
Code	Name		Style	Show	Link
ZN	Zinc ion				PoSSuM
CRB	[1r-(1alpha,3beta,4alpha,5beta)]-5-(phosphonomethyl)-1,3,4-trihydroxycyclohexane-1-carboxylic acid				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 1XAI

Code :

1XAI PDBj RCSB PDB PDBe

Header :

LYASE

Title :

CRYSTAL STRUCTURE OF STAPHLYOCOCCUS AUREUS 3-DEHYDROQUINATE SYNTHASE (DHQS) IN COMPLEX WITH ZN2+, NAD+ AND CARBAPHOSPHONATE

Release Data :

2005-03-01

Compound :

mol_id	molecule	chains	synonym
1	3-dehydroquinate synthase	A,B	SaDHQS
	ec: 4.2.3.4

Source :

mol_id	organism_scientific	expression_system
1	Staphylococcus aureus (taxid:1280)	Escherichia coli (taxid:562)
	gene: aroB expression_system_strain: BL21(DE3 pLysS) expression_system_vector_type: plasmid expression_system_plasmid: pMUT27

Authors :

Nichols, C.E., Ren, J., Leslie, K., Dhaliwal, B., Lockyer, M., Charles, I., Hawkins, A.R., Stammers, D.K.

Keywords :

SHIKIMATE PATHWAY, AROMATIC AMINO ACID BIOSYNTHESIS, DHQS, SADHQS, CLOSED FORM, FORM B, DOMAIN MOVEMENT, CYCLASE, LYASE

Exp. method :

X-RAY DIFFRACTION ( 2.30 Å )

Citation :

Comparison of ligand induced conformational changes and domain closure mechanisms, between prokaryotic and eukaryotic dehydroquinate synthases.

Nichols, C.E.,Ren, J.,Leslie, K. et al.
(2004) J.Mol.Biol. 343 : 533 - 546

Chain :

A, B

UniProt :

Q6GGU4 (AROB_STAAR)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3- dehydroquinate + phosphate	4.2.3.4	HAMAP-Rule:MF_00110
	-	HAMAP-Rule:MF_00110
Cofactor:	Evidence:	Note:
NAD(+)	ECO:0000255 \| HAMAP-Rule:MF_00110	-
Zn(2+)	ECO:0000255 \| HAMAP-Rule:MF_00110 ECO:0000255 \| HAMAP-Rule:MF_00110	Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).

PDB ID: 1XAI